Document Detail

Regulation of intestinal protein metabolism by amino acids.
MedLine Citation:
PMID:  22643845     Owner:  NLM     Status:  Publisher    
Gut homeostasis plays a major role in health and may be regulated by quantitative and qualitative food intake. In the intestinal mucosa, an intense renewal of proteins occurs, at approximately 50 % per day in humans. In some pathophysiological conditions, protein turnover is altered and may contribute to intestinal or systemic diseases. Amino acids are key effectors of gut protein turnover, both as constituents of proteins and as regulatory molecules limiting intestinal injury and maintaining intestinal functions. Many studies have focused on two amino acids: glutamine, known as the preferential substrate of rapidly dividing cells, and arginine, another conditionally essential amino acid. The effects of glutamine and arginine on protein synthesis appear to be model and condition dependent, as are the involved signaling pathways. The regulation of gut protein degradation by amino acids has been minimally documented until now. This review will examine recent data, helping to better understand how amino acids regulate intestinal protein metabolism, and will explore perspectives for future studies.
Julien Bertrand; Alexis Goichon; Pierre Déchelotte; Moïse Coëffier
Related Documents :
3128045 - Lipid droplet accumulation in the heart during fasting.
1141615 - Comprehensive evaluation of fatty acids in foods. iii. eggs and egg products.
8466285 - Bound lipids liberated by alkaline hydrolysis after exhaustive extraction of pulverized...
12137275 - Extraction of lipids from mortierella alpina and enrichment of arachidonic acid from th...
9602205 - Effect of pasteurization on long chain polyunsaturated fatty acid levels and enzyme act...
16382685 - Three etiologic facets of dandruff and seborrheic dermatitis: malassezia fungi, sebaceo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-29
Journal Detail:
Title:  Amino acids     Volume:  -     ISSN:  1438-2199     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
INSERM UMR 1073, 22 bd Gambetta, 76183, Rouen cedex, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Wards in the keyway: amino acids with anomalous pK (a)s in calycins.
Next Document:  Abundance of amino acid transporters involved in mTORC1 activation in skeletal muscle of neonatal pi...