Document Detail

Regulation of intestinal blood flow with increased intraluminal pressure.
MedLine Citation:
PMID:  4068689     Owner:  NLM     Status:  MEDLINE    
To better characterize the mechanisms which regulate intestinal blood flow (IBF), we studied the effects of gradual and rapid increases in intraluminal pressure (LP) in anesthetized canines. Polarographic measurements of hydrogen washout allowed repeated assessment of IBF (ml/min X g) in control (CL) and distended (DL) autoperfused small intestinal loops. In group I (n = 7) graded increases in LP (mm Hg) were produced by saline inflation. In group II (n = 4), IBF was measured before and after intraarterial aminophylline (adenosine blockade); LP was then rapidly raised to 24 mm Hg. IBF was unchanged by time (CL 0.64 +/- 0.24) or gradual distension (DL 0.65 +/- 0.28 at mean maximal LP = 26). Aminophylline did not change IBF at LP = 0. Rapid distension after adenosine blockade was accompanied by immediate increases in IBF (0.96 +/- 0.41, P less than 0.05) and decreased resistance (50 +/- 25% control). IBF is maintained despite gradual increases in luminal pressure. Blockade of adenosine, an intestinal vasodilator, does not inhibit this response; hyperemia associated with rapid distension is not impaired. We conclude that autoregulation of IBF during distension is not accomplished by an adenosine mediated metabolic mechanism.
D P Hurley; P C Kremser; B L Gewertz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of surgical research     Volume:  39     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1985-12-30     Completed Date:  1985-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  510-6     Citation Subset:  IM    
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MeSH Terms
Adenosine / pharmacology
Aminophylline / pharmacology
Intestines / blood supply*
Regional Blood Flow / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
317-34-0/Aminophylline; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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