Document Detail


Regulation of the intercellular adhesin locus regulator (icaR) by SarA, sigmaB, and IcaR in Staphylococcus aureus.
MedLine Citation:
PMID:  18658265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The staphylococcal accessory regulator SarA and the alternative sigma factor sigma(B) have been previously identified as positive regulators, and IcaR as a negative regulator, of icaADBC expression. Here, we show that in Staphylococcus aureus SarA and sigma(B) are also required for icaR expression and that IcaR does not have a significant effect on its own expression.
Authors:
Nuno Cerca; Jamie L Brooks; Kimberly K Jefferson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-07-25
Journal Detail:
Title:  Journal of bacteriology     Volume:  190     ISSN:  1098-5530     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2009-01-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6530-3     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, Virginia Commonwealth University, P.O. Box 980678, Richmond, VA 23928, USA.
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MeSH Terms
Descriptor/Qualifier:
Adhesins, Bacterial / genetics*,  metabolism,  physiology
Bacterial Proteins / genetics*,  metabolism
Biofilms / growth & development
Gene Expression Regulation, Bacterial*
Genetic Complementation Test
Models, Biological
Mutation
Promoter Regions, Genetic / genetics
Sigma Factor / genetics,  metabolism
Staphylococcus aureus / genetics*,  metabolism,  physiology
Trans-Activators / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
R01 AI068892/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Adhesins, Bacterial; 0/Bacterial Proteins; 0/SarA protein, bacterial; 0/Sigma Factor; 0/Trans-Activators
Comments/Corrections

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