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Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets.
MedLine Citation:
PMID:  21750413     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Free fatty acids regulate insulin secretion through metabolic and intracellular signaling mechanisms such as induction of malonyl-CoA/ long-chain CoA pathway, production of lipid derivatives, GPRs (G protein coupled receptors) activation and modulation of calcium currents. Fatty acids (FA) are also important inducers of ROS (reactive oxygen species) production in β-cells. Production of ROS for short time is associated with an increase in GSIS (glucose-stimulated insulin secretion), but excessive or sustained production of ROS is negatively correlated with the insulin secretory process. Several mechanisms for FA modulation of ROS production by pancreatic β-cells have been proposed: control of mitochondrial complexes and electron transport, induction of uncoupling proteins, NADPH oxidase activation, interaction with the renin-angiotensin system, and modulation of antioxidant defenses. The major sites of superoxide production within mitochondria derive from complexes I and III. The amphiphilic nature of FA favors their incorporation into mitochondrial membranes, altering the membrane fluidity and facilitating the electron leak. The extra-mitochondrial ROS production induced by FA through NADPH oxidase complex is also an important source of these species.
Authors:
Maria Fernanda Graciano; Maíra Valle; Anjaneyulu Kowluru; Rui Curi; Angelo Carpinelli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-01
Journal Detail:
Title:  Islets     Volume:  3     ISSN:  1938-2022     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101495366     Medline TA:  Islets     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Physiology and Biophysics; Institute of Biomedical Sciences; University of Sao Paulo; Sao Paulo, Brazil.
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