Document Detail

Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets.
MedLine Citation:
PMID:  21750413     Owner:  NLM     Status:  MEDLINE    
Free fatty acids regulate insulin secretion through metabolic and intracellular signaling mechanisms such as induction of malonyl-CoA/long-chain CoA pathway, production of lipids, GPRs (G protein-coupled receptors) activation and the modulation of calcium currents. Fatty acids (FA) are also important inducers of ROS (reactive oxygen species) production in β-cells. Production of ROS for short periods is associated with an increase in GSIS (glucose-stimulated insulin secretion), but excessive or sustained production of ROS is negatively correlated with the insulin secretory process. Several mechanisms for FA modulation of ROS production by pancreatic β-cells have been proposed, such as the control of mitochondrial complexes and electron transport, induction of uncoupling proteins, NADPH oxidase activation, interaction with the renin-angiotensin system, and modulation of the antioxidant defense system. The major sites of superoxide production within mitochondria derive from complexes I and III. The amphiphilic nature of FA favors their incorporation into mitochondrial membranes, altering the membrane fluidity and facilitating the electron leak. The extra-mitochondrial ROS production induced by FA through the NADPH oxidase complex is also an important source of these species in β-cells.
Maria Fernanda Rodrigues Graciano; Maíra M R Valle; Anjan Kowluru; Rui Curi; Angelo R Carpinelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-09-01
Journal Detail:
Title:  Islets     Volume:  3     ISSN:  1938-2022     ISO Abbreviation:  Islets     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-09-08     Completed Date:  2012-01-05     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495366     Medline TA:  Islets     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-23     Citation Subset:  IM    
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MeSH Terms
Fatty Acids, Nonesterified / metabolism*
Insulin / metabolism*,  secretion
Insulin-Secreting Cells / metabolism*,  secretion
Oxidative Stress / physiology*
Reactive Oxygen Species / metabolism*
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Insulin; 0/Reactive Oxygen Species

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