| Regulation of inducible BALT formation and contribution to immunity and pathology. | |
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MedLine Citation:
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PMID: 20811344 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Inducible bronchus-associated lymphoid tissue (iBALT) is an organized tertiary lymphoid structure that is not pre-programmed but develops in response to infection or under chronic inflammatory conditions. Emerging research has shown that iBALT provides a niche for T-cell priming and B-cell education to assist in the clearance of infectious agents, highlighting the prospect that iBALT may be engineered and harnessed to enhance protective immunity against respiratory pathogens. Although iBALT formation is associated with several canonical factors of secondary lymphoid organogenesis such as lymphotoxin-α and the homeostatic chemokines, CXCL13, CCL19, and CCL21, these cytokines are not mandatory for its formation, even though they influence its organization and function. Similarly, lymphoid tissue-inducer cells are not a requisite of iBALT formation. In contrast, dendritic cells are emerging as pivotal players required to form and sustain the presence of iBALT. Regulatory T cells appear to be able to attenuate the development of iBALT, although the underlying mechanisms remain ill-defined. In this review, we discuss facets unique to iBALT induction, the cellular subsets, and molecular cues that govern this process, and the contribution of this ectopic structure toward the generation of immune responses in the pulmonary compartment. |
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Authors:
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S Y Foo; S Phipps |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-01 |
Journal Detail:
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Title: Mucosal immunology Volume: 3 ISSN: 1935-3456 ISO Abbreviation: Mucosal Immunol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101299742 Medline TA: Mucosal Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 537-44 Citation Subset: IM |
Affiliation:
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Centre for Asthma and Respiratory Diseases (CARD), School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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