Document Detail

Regulation of hunger and satiety in man.
MedLine Citation:
PMID:  1752065     Owner:  NLM     Status:  MEDLINE    
From the perspective presented in this minireview, it is clear that a variety of psychological and physiological factors interact to regulate feeding behavior. The hunger-satiety cycle involves preabsorptive and postabsorptive humoral and neuronal mechanisms. Psychological, social and environmental factors, nutrients and metabolical processes and gastric contractions originate hunger signals. Eating, in turn, activates inhibitory signals to produce satiety. Because of the delay between the swallowing of food and the digestion of food, the satiety mechanism requires a short-term signal to prevent over-eating. This short-term satiety signal is activated by psychological factors (such as sensory-specific satiety), chemical senses (taste and smell) and mechanical factors related to the process of swallowing and gastric distension. The long-term satiety is then activated by the chemoreception of nutrients and peptides by the gastrointestinal system (including the liver), the CNS and by intrinsic CNS mechanisms. The fine regulation of feeding behavior through these mechanisms will ensure the maintenance of normal energy metabolism. It is important to note, however, that despite all the efforts that have gone into the study of peripheral and central mechanisms of ingestive behavior--expressed in thousands of publications related to the anatomy, chemistry and metabolism, physiology and behavioral aspects of feeding--we will lack an understanding of the interactions among signals within a system or among different systems.
C R Plata-Salamán
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Digestive diseases (Basel, Switzerland)     Volume:  9     ISSN:  0257-2753     ISO Abbreviation:  Dig Dis     Publication Date:  1991  
Date Detail:
Created Date:  1992-01-28     Completed Date:  1992-01-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701186     Medline TA:  Dig Dis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  253-68     Citation Subset:  IM    
School of Life and Health Sciences, University of Delaware, Newark.
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MeSH Terms
Acute Disease
Adipose Tissue / physiology
Brain / physiology
Chronic Disease
Digestive System Physiological Phenomena
Eating / physiology*,  psychology
Energy Metabolism / physiology
Hunger / physiology*
Satiation / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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