| Regulation of human skeletal muscle perfusion and its heterogeneity during exercise in moderate hypoxia. | |
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MedLine Citation:
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PMID: 20427728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although many effects of both acute and chronic hypoxia on the circulation are well characterized, the distribution and regulation of blood flow (BF) heterogeneity in skeletal muscle during systemic hypoxia is not well understood in humans. We measured muscle BF within the thigh muscles of nine healthy young men using positron emission tomography during one-leg dynamic knee extension exercise in normoxia and moderate physiological systemic hypoxia (14% O(2) corresponding to approximately 3,400 m of altitude) without and with local adenosine receptor inhibition with femoral artery infusion of aminophylline. Systemic hypoxia reduced oxygen extraction of the limb but increased muscle BF, and this flow increment was confined solely to the exercising quadriceps femoris muscle. Exercising muscle BF heterogeneity was reduced from rest (P = 0.055) but was not affected by hypoxia. Adenosine receptor inhibition had no effect on capillary BF during exercise in either normoxia or hypoxia. Finally, one-leg exercise increased muscle BF heterogeneity both in the resting posterior hamstring part of the exercising leg and in the resting contralateral leg, whereas mean BF was unchanged. In conclusion, the results show that increased BF during one-leg exercise in moderate hypoxia is confined only to the contracting muscles, and the working muscle hyperemia appears not to be directly mediated by adenosine. Increased flow heterogeneity in noncontracting muscles likely reflects sympathetic nervous constraints to curtail BF increments in areas other than working skeletal muscles, but this effect is not potentiated in moderate systemic hypoxia during small muscle mass exercise. |
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Authors:
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Ilkka H Heinonen; Jukka Kemppainen; Kimmo Kaskinoro; Juha E Peltonen; Ronald Borra; Markus Lindroos; Vesa Oikonen; Pirjo Nuutila; Juhani Knuuti; Robert Boushel; Kari K Kalliokoski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-28 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 299 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-25 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R72-9 Citation Subset: IM |
Affiliation:
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Turku PET Centre, Turku University Hospital, University of Turku, Turku, Finland. ilkka.heinonen@tyks.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology Adult Altitude Anoxia / physiopathology*, radionuclide imaging Capillaries / physiopathology Exercise / physiology* Hemodynamics / physiology Humans Hyperemia / radionuclide imaging Leg / blood supply, physiology, physiopathology Male Muscle Contraction Muscle, Skeletal / blood supply*, physiology*, radionuclide imaging Oxygen / blood Perfusion Quadriceps Muscle / blood supply*, physiopathology Receptors, Purinergic P1 / metabolism Rest / physiology Sympathetic Nervous System / physiology, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Purinergic P1; 58-61-7/Adenosine; 7782-44-7/Oxygen |
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