Document Detail

Regulation of high affinity taurine transport in goldfish and rat retinal cells.
MedLine Citation:
PMID:  11787628     Owner:  NLM     Status:  MEDLINE    
Adaptive regulation and modulation by phosphorylation are mechanisms by which some cells control taurine transport. Goldfish and rat retinal cells were incubated with the activator of protein kinase C, phorbol 12,13-dibutyrate (PDBu), or the inhibitor of protein phosphatases, okadaic acid (OKA). OKA, 1 nM, inhibited the uptake of taurine at short period of incubation in goldfish retinal cells, and at low concentrations in rat retinal cells incubated with the inhibitor for 1 h. PDBu treatment did not produce significant effects. Isolated Müller cells from the goldfish retina presented a clear adaptive regulation and a decrease of taurine uptake by increasing phosphorylation either by the stimulation of PKC with PDBu or the inhibition of phosphatases with OKA.
L Lima; S Cubillos; A Guerra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  483     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2000  
Date Detail:
Created Date:  2002-01-11     Completed Date:  2002-01-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  431-40     Citation Subset:  IM    
Laboratorio de Neuroquímica, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas.
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MeSH Terms
Biological Transport
Cells, Cultured
Enzyme Activation
Enzyme Inhibitors / pharmacology
Okadaic Acid / pharmacology
Phorbol 12,13-Dibutyrate / pharmacology
Phosphoprotein Phosphatases / antagonists & inhibitors*
Protein Kinase C / metabolism*
Retina / cytology,  metabolism*
Taurine / metabolism*,  pharmacology
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Phorbols; 107-35-7/Taurine; 17673-25-5/phorbol; 37558-16-0/Phorbol 12,13-Dibutyrate; 78111-17-8/Okadaic Acid; EC Kinase C; EC Phosphatases

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