Document Detail

Regulation of hepatocarcinogenesis by microRNAs.
MedLine Citation:
PMID:  23276969     Owner:  NLM     Status:  In-Data-Review    
Liver cancer (hepatocellular carcinoma, HCC) is a major malignancy worldwide. Etiologically, hepatocarcinogenesis is closely associated with HBV and HCV infections; however, its underlying molecular mechanism is not completely understood. MicroRNAs are a class of small non-coding RNAs that negatively regulate gene expression by interacting with the 3'UTR of protein-coding mRNA. MicroRNAs are implicated in nearly all major biological and cellular events, and recent findings further link microRNA deregulation to human carcinogenesis. In this review, we will focus on the aberrant expression of miRNAs in liver cancer and the pathological implications and molecular functions of some well-characterized oncogenic and tumor suppressive miRNAs. Finally, the clinical prospect of miRNAs as a novel diagnostic and therapeutic intervention will be discussed.
Chun-Ming Wong; Alan Ka-Lun Kai; Felice Ho-Ching Tsang; Irene Oi-Lin Ng
Related Documents :
23572149 - High cd74 expression correlates with zap70 expression in b cell chronic lymphocytic leu...
24668219 - Computational analyses reveal a prognostic impact of tulp3 as a transcriptional master ...
1330539 - A regulatory element that mediates co-operation between a pea3-ap-1 element and an ap-1...
23050139 - Evaluation of norepinephrine transporter expression and metaiodobenzylguanidine avidity...
12482979 - Novel transcriptional potentiation of beta2/neurod on the secretin gene promoter by the...
19193899 - The serum response factor and a putative novel transcription factor regulate expression...
8119129 - Ecdysone receptor expression in the cns correlates with stage-specific responses to ecd...
9661919 - Positivity of the proliferation marker ki-67 in noncycling cells.
15095479 - Expression of pten in malignant and non-malignant human prostate tissues: comparison wi...
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  5     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-60     Citation Subset:  IM    
University Pathology Building, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Microtechnology-based three-dimensional spheroid formation.
Next Document:  Obesity and colorectal cancer.