| Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cells. | |
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MedLine Citation:
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PMID: 12850286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemopexin (Hx) is an acute-phase hepatic protein, whose transcription is upregulated by IL-6. The transcription rate of Hx was found to be increased 11-fold by the calcium ionophore A23187, 25-fold by the calcium ionophore ionomycin, and 4-5-fold by phorbol 12-myristate 13-acetate (PMA) in serum-starved H4IIE rat hepatoma cells. Insulin did not affect the transcription rate of Hx. These findings are consistent with involvement of intracellular calcium concentrations and activation of protein kinase C (PKC) action in the regulation of Hx. |
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Authors:
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Susan E Stred; Deborah Cote; Ruth S Weinstock; Joseph L Messina |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 204 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-09 Completed Date: 2004-04-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
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Languages: eng Pagination: 111-6 Citation Subset: IM |
Affiliation:
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Cell and Molecular Biology Program and Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Carcinoma, Hepatocellular / pathology* Cell Line, Tumor Gene Expression Regulation* / drug effects Hemopexin / genetics* Insulin / pharmacology Ionophores / pharmacology Kinetics Protein Kinase C / metabolism Rats Tetradecanoylphorbol Acetate / pharmacology Transcription, Genetic* / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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DK02114/DK/NIDDK NIH HHS; DK54440/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ionophores; 11061-68-0/Insulin; 16561-29-8/Tetradecanoylphorbol Acetate; 7440-70-2/Calcium; 9013-71-2/Hemopexin; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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