Document Detail

Regulation of the hapten-specific T cell response. I. Preferential induction of hyporesponsiveness to the D-end of the major histocompatibility complex in the hapten-specific cytotoxic T cell response.
MedLine Citation:
PMID:  6195256     Owner:  NLM     Status:  MEDLINE    
In this paper we have examined the phenomenon of hapten-specific tolerance in the cytolytic T lymphocyte (CTL), using the trinitrophenyl (TNP) and azobenzenearsonate haptens. We found that the H-2 K and H-2 D-end restricted CTL in H-2a mice are differentiable in the ease with which they are tolerized to the TNP hapten. With TNP modified syngeneic spleen cells (TNP-SC), or low amounts of trinitrobenzylsulfonic acid as tolerogen, preferential hyporesponsiveness of D-end restricted CTL can be observed. Larger doses of hapten, e.g. a higher amount of trinitrobenzylsulfonic acid, will tolerize both K- and D-end restricted TNP-specific CTL in H-2a mice. The phenomenon of preferential D-end restricted CTL hyporesponsiveness is not observed in H-2d, H-2k, or H-2b mice, nor is it observed in H-2a mice with respect to the azobenzenearsonate hapten. We have also shown that the clones of CTL responsible for lysis of TNP-modified allogeneic targets (cross-reactive lysis) in H-2a mice probably overlap with the D-end restricted TNP-specific CTL since D-end restricted hyporesponsiveness induced by intravenous injection of TNP spleen cells also results in the elimination of cross-reactive lysis of TNP-modified allogeneic targets. The possible mechanisms of preferential D-end hyporesponsiveness to the TNP hapten in the H-2a mice as well as its significance and relationship to previous work in this area are discussed in this paper.
C F Scott; M Tsurufuji; B Benacerraf; M S Sy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  131     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2184-9     Citation Subset:  AIM; IM    
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MeSH Terms
Cross Reactions
Cytotoxicity, Immunologic
Epitopes / genetics,  immunology*
H-2 Antigens / genetics,  immunology*
Immune Tolerance*
Lymphocyte Transfusion
Mice, Inbred A
Mice, Inbred C3H
Mice, Inbred C57BL
Spleen / cytology
T-Lymphocytes, Cytotoxic / immunology*
Trinitrobenzenesulfonic Acid / administration & dosage,  immunology
p-Azobenzenearsonate / immunology
Grant Support
Reg. No./Substance:
0/Epitopes; 0/H-2 Antigens; 2508-19-2/Trinitrobenzenesulfonic Acid; 7334-23-8/p-Azobenzenearsonate

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