| Regulation of growth arrest in senescence: telomere damage is not the end of the story. | |
| | |
MedLine Citation:
|
PMID: 16229875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
After a limited number of divisions, most eukaryotic cells grown in culture will undergo a terminal growth arrest called cellular senescence. This growth arrest is thought to be a consequence of progressive telomere shortening that occurs due to incomplete DNA replication of the chromosome ends. In addition, cellular senescence can also be induced by a number of environmental stresses and signaling imbalances which are independent of telomere shortening. The cyclin dependent kinase inhibitors p21 and p16(INK4a) have been shown to execute and maintain the cell cycle arrest in senescence but the nature of the signals that cause upregulation of these inhibitors in senescent cells are only now starting to be discovered. Here we will review the current literature that leads us to propose a model how independent signals activate distinct signaling pathways to regulate p21 and p16(INK4a) levels in senescent cells. |
| | |
Authors:
|
Utz Herbig; John M Sedivy |
Related Documents
:
|
7753545 - The interactions of e2f with prb and with p107 are regulated via the phosphorylation of... 8259215 - A new regulatory motif in cell-cycle control causing specific inhibition of cyclin d/cdk4. 19466465 - Explaining the inhibition of cyclin-dependent kinase 5 by peptides derived from p25 wit... 17513615 - Induction of p21 protein protects against sulforaphane-induced mitotic arrest in lncap ... 7510705 - Basic fibroblast growth factor-induced low density lipoprotein receptor transcription a... 11585105 - Association of trypsin-2 with activation of gelatinase b and collagenase-2 in human bro... |
Publication Detail:
|
Type: Journal Article; Review Date: 2005-10-17 |
Journal Detail:
|
Title: Mechanisms of ageing and development Volume: 127 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-12-05 Completed Date: 2006-04-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: Ireland |
Other Details:
|
Languages: eng Pagination: 16-24 Citation Subset: IM |
Affiliation:
|
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship Street, Box G-E438, Providence, RI 02903, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Aging / physiology* Cell Proliferation Cyclin-Dependent Kinase Inhibitor p16 / metabolism Cyclin-Dependent Kinase Inhibitor p21 / metabolism Humans Telomere / metabolism, pathology* Up-Regulation |
| Chemical | |
Reg. No./Substance:
|
0/Cyclin-Dependent Kinase Inhibitor p16; 0/Cyclin-Dependent Kinase Inhibitor p21 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Responses of European eel (Anguilla anguilla L.) circulating phagocytes to an in situ closed pulp mi...
Next Document: Imbalance between phytoplankton production and bacterial carbon demand in relation to mucilage forma...