Document Detail

Regulation of granulopoiesis by transcription factors and cytokine signals.
MedLine Citation:
PMID:  10865962     Owner:  NLM     Status:  MEDLINE    
The development of mature granulocytes from hematopoietic precursor cells is controlled by a myriad of transcription factors which regulate the expression of essential genes, including those encoding growth factors and their receptors, enzymes, adhesion molecules, and transcription factors themselves. In particular, C/EBPalpha, PU.1, CBF, and c-Myb have emerged as critical players during early granulopoiesis. These transcription factors interact with one another as well as other factors to regulate the expression of a variety of genes important in granulocytic lineage commitment. An important goal remains to understand in greater detail how these various factors act in concert with signals emanating from cytokine receptors to influence the various steps of maturation, from the pluripotent hematopoietic stem cell, to a committed myeloid progenitor, to myeloid precursors, and ultimately to mature granulocytes.
A C Ward; D M Loeb; A A Soede-Bobok; I P Touw; A D Friedman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Leukemia     Volume:  14     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-10     Completed Date:  2000-07-10     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  973-90     Citation Subset:  IM    
Institute of Hematology, Erasmus University Rotterdam, The Netherlands.
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MeSH Terms
Cytokines / metabolism,  physiology*
Granulocytes / cytology*
Leukopoiesis / physiology*
Signal Transduction*
Transcription Factors / metabolism,  physiology*
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Transcription Factors

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