Document Detail


Regulation of glycogen synthase and phosphorylase during recovery from high-intensity exercise in the rat.
MedLine Citation:
PMID:  9078277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine the role of the phosphorylation state of glycogen synthase and glycogen phosphorylase in the regulation of muscle glycogen repletion in fasted animals recovering from high-intensity exercise. Groups of rats were swum to exhaustion and allowed to recover for up to 120 min without access to food. Swimming to exhaustion caused substantial glycogen breakdown and lactate accumulation in the red, white and mixed gastrocnemius muscles, whereas the glycogen content in the soleus muscle remained stable. During the first 40 min of recovery, significant repletion of glycogen occurred in all muscles examined except the soleus muscle. At the onset of recovery, the activity ratios and fractional velocities of glycogen synthase in the red, white and mixed gastrocnemius muscles were higher than basal, but returned to pre-exercise levels within 20 min after exercise. In contrast, after exercise the activity ratios of glycogen phosphorylase in the same muscles were lower than basal, and increased to pre-exercise levels within 20 min. This pattern of changes in glycogen synthase and phosphorylase activities, never reported before, suggests that the integrated regulation of the phosphorylation state of both glycogen synthase and phosphorylase might be involved in the control of glycogen deposition after high-intensity exercise.
Authors:
L Bräu; L D Ferreira; S Nikolovski; G Raja; T N Palmer; P A Fournier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  322 ( Pt 1)     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-15     Completed Date:  1997-04-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM; S    
Affiliation:
Department of Biochemistry, University of Western Australia, Nedlands, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Enzyme Activation
Glycogen / metabolism
Glycogen Synthase / metabolism*
Male
Muscle, Skeletal / enzymology,  metabolism
Phosphorylases / metabolism*
Phosphorylation
Physical Conditioning, Animal / physiology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
9005-79-2/Glycogen; EC 2.4.1.-/Phosphorylases; EC 2.4.1.11/Glycogen Synthase
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