| Regulation of glucose kinetics during exercise by the glucagon-like peptide-1 receptor. | |
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MedLine Citation:
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PMID: 22890715 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In response to oral glucose, glucagon-like peptide-1 receptor (Glp1r) knockout (Glp1r-/-) mice become hyperglycemic due to impaired insulin secretion. Exercise also induces hyperglycemia in Glp1r-/- mice. In contrast to oral glucose, exercise decreases insulin secretion. This implies that exercise-induced hyperglycemia in Glp1r-/- mice results from the loss of a non-insulinotropic effect mediated by the Glp1r. Muscle glucose uptake (MGU) is normal in exercising Glp1r-/- mice. Thus, we hypothesize that exercise-induced hyperglycemia in Glp1r-/- mice is due to excessive hepatic glucose production (HGP). Wild-type (Glp1r+/+) and Glp1r-/- mice implanted with venous and arterial catheters underwent treadmill exercise or remained sedentary for 30 min. [3-3H]glucose was used to estimate rates of glucose appearance (Ra), an index of HGP, and disappearance (Rd). 2[14C]deoxyglucose was used to assess MGU. Glp1r-/- mice displayed exercise-induced hyperglycemia due to an excessive increase in Ra but normal Rd and MGU. Exercise-induced glucagon levels were ~2-fold higher in Glp1r-/- mice, resulting in a~2-fold higher glucagon:insulin ratio. Since inhibition of the central Glp1r stimulates HGP, we tested whether intracerebroventricular (ICV) infusion of the Glp1r antagonist exendin(9-39) (Ex9) in Glp1r+/+ mice would result in exercise-induced hyperglycemia. ICV Ex9 did not enhance glucose levels or HGP during exercise, suggesting that glucoregulatory effects of Glp1 during exercise are mediated via the pancreatic Glp1r. In conclusion, functional disruption of the Glp1r results in exercise-induced hyperglycemia associated with an excessive increase in glucagon secretion and HGP. These results suggest an essential role for basal Glp1r signaling in the suppression of alpha cell secretion during exercise. |
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Authors:
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Melissa A Burmeister; Deanna P Bracy; Freyja D James; Rochelle M Holt; Jennifer E Ayala; Emily M King; David H Wasserman; Daniel J Drucker; Julio E Ayala |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-13 |
Journal Detail:
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Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Sanford-Burnham Medical Research Institute at Lake Nona; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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