| Regulation of gene expression by hypoxia: a molecular approach. | |
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MedLine Citation:
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PMID: 9407603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxygen is a strict requirement for cell function. The cellular mechanisms by which organisms detect and respond to changes in oxygen tension remain a major unanswered question in pulmonary physiology. Part of the difficulty in addressing this question is due to the limited scope of experiments that can be performed in vivo. In the past few years, several laboratories have begun to make progress in this area, using a variety of cell culture model systems and sophisticated genetic manipulations. Here, we review the current state of knowledge of regulation of gene expression by hypoxia, and describe novel experimental approaches that promise to broaden our understanding of how cells and whole organisms respond to alterations in O2 tension. |
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Authors:
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D Beitner-Johnson; G E Shull; J R Dedman; D E Millhorn |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Respiration physiology Volume: 110 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-02-04 Completed Date: 1998-02-04 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 87-97 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cellular Physiology, University of Cincinnati, College of Medicine, OH 45267-0576, USA. dana.johnson@uc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / genetics* Cells, Cultured Gene Expression Regulation / physiology* Humans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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