Document Detail

Regulation of gene expression by dietary fat.
MedLine Citation:
PMID:  10448517     Owner:  NLM     Status:  MEDLINE    
Dietary fat is an important macronutrient for the growth and development of all organisms. In addition to its role as an energy source and its effects on membrane lipid composition, dietary fat has profound effects on gene expression, leading to changes in metabolism, growth, and cell differentiation. The effects of dietary fat on gene expression reflect an adaptive response to changes in the quantity and type of fat ingested. Specific fatty acid-regulated transcription factors have been identified in bacteria, amphibians, and mammals. In mammals, these factors include peroxisome proliferator-activated receptors (PPAR alpha, -beta, and -gamma), HNF4 alpha, NF kappa B, and SREBP1c. These factors are regulated by (a) direct binding of fatty acids, fatty acyl-coenzyme A, or oxidized fatty acids; (b) oxidized fatty acid (eicosanoid) regulation of G-protein-linked cell surface receptors and activation of signaling cascades targeting the nucleus; or (c) oxidized fatty acid regulation of intracellular calcium levels, which affect cell signaling cascades targeting the nucleus. At the cellular level, the physiological response to fatty acids will depend on (a) the quantity, chemistry, and duration of the fat ingested; (b) cell-specific fatty acid metabolism (oxidative pathways, kinetics, and competing reactions); (c) cellular abundance of specific nuclear and membrane receptors; and (d) involvement of specific transcription factors in gene expression. These mechanisms are involved in the control of carbohydrate and lipid metabolism, cell differentiation and growth, and cytokine, adhesion molecule, and eicosanoid production. The effects of fatty acids on the genome provide new insight into how dietary fat might play a role in health and disease.
D B Jump; S D Clarke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  19     ISSN:  0199-9885     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  1999  
Date Detail:
Created Date:  1999-10-04     Completed Date:  1999-10-04     Revised Date:  2012-05-09    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-90     Citation Subset:  IM    
Department of Physiology and Biochemistry, Michigan State University, East Lansing 48824, USA.
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MeSH Terms
Arteriosclerosis / etiology
Bacteria / genetics
Dietary Fats / administration & dosage,  pharmacology*
Fatty Acids / pharmacology
Gene Expression Regulation*
Hyperlipidemias / etiology
Neoplasms / etiology
Yeasts / genetics
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids

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