| Regulation of gene expression by dietary fat. | |
| | |
MedLine Citation:
|
PMID: 10448517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dietary fat is an important macronutrient for the growth and development of all organisms. In addition to its role as an energy source and its effects on membrane lipid composition, dietary fat has profound effects on gene expression, leading to changes in metabolism, growth, and cell differentiation. The effects of dietary fat on gene expression reflect an adaptive response to changes in the quantity and type of fat ingested. Specific fatty acid-regulated transcription factors have been identified in bacteria, amphibians, and mammals. In mammals, these factors include peroxisome proliferator-activated receptors (PPAR alpha, -beta, and -gamma), HNF4 alpha, NF kappa B, and SREBP1c. These factors are regulated by (a) direct binding of fatty acids, fatty acyl-coenzyme A, or oxidized fatty acids; (b) oxidized fatty acid (eicosanoid) regulation of G-protein-linked cell surface receptors and activation of signaling cascades targeting the nucleus; or (c) oxidized fatty acid regulation of intracellular calcium levels, which affect cell signaling cascades targeting the nucleus. At the cellular level, the physiological response to fatty acids will depend on (a) the quantity, chemistry, and duration of the fat ingested; (b) cell-specific fatty acid metabolism (oxidative pathways, kinetics, and competing reactions); (c) cellular abundance of specific nuclear and membrane receptors; and (d) involvement of specific transcription factors in gene expression. These mechanisms are involved in the control of carbohydrate and lipid metabolism, cell differentiation and growth, and cytokine, adhesion molecule, and eicosanoid production. The effects of fatty acids on the genome provide new insight into how dietary fat might play a role in health and disease. |
| | |
Authors:
|
D B Jump; S D Clarke |
Related Documents
:
|
3367697 - Perfluoro-n-decanoic acid: induction of peroxisomal beta-oxidation by a fatty acid with... 17716997 - Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sc... 18969037 - Chromotropic acid-formaldehyde reaction in strongly acidic media. the role of dissolved... 8904527 - In vitro inactivation of mammalian methionine synthase by nitric oxide. 6126217 - Lack of coordinated regulation of lipogenic enzymes in a human breast cell line, skbr3. 1730027 - Stability properties of aplysia oxymyoglobin: effect of esterification of the heme prop... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Annual review of nutrition Volume: 19 ISSN: 0199-9885 ISO Abbreviation: Annu. Rev. Nutr. Publication Date: 1999 |
Date Detail:
|
Created Date: 1999-10-04 Completed Date: 1999-10-04 Revised Date: 2012-05-09 |
Medline Journal Info:
|
Nlm Unique ID: 8209988 Medline TA: Annu Rev Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 63-90 Citation Subset: IM |
Affiliation:
|
Department of Physiology and Biochemistry, Michigan State University, East Lansing 48824, USA. Jump@pilot.msu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arteriosclerosis / etiology Bacteria / genetics Dietary Fats / administration & dosage, pharmacology* Fatty Acids / pharmacology Gene Expression Regulation* Humans Hyperlipidemias / etiology Neoplasms / etiology Yeasts / genetics |
| Grant Support | |
ID/Acronym/Agency:
|
DK43220/DK/NIDDK NIH HHS; DK46363/DK/NIDDK NIH HHS; DK53872/DK/NIDDK NIH HHS; R01 DK043220/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Fatty Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development of food preferences.
Next Document: Carrier-mediated membrane transport of folates in mammalian cells.