| Regulation of gastric and pancreatic lipase secretion by CCK and cholinergic mechanisms in humans. | |
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MedLine Citation:
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PMID: 9277416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric lipase (HGL) contributes significantly to fat digestion. However, little is known about its neurohormonal regulation in humans. We studied the role of CCK and cholinergic mechanisms in the postprandial regulation of HGL and pancreatic lipase (HPL) secretion in six healthy subjects. Gastric emptying of a mixed meal and outputs of HGL, pepsin, acid, and HPL were determined with a double-indicator technique. Three experiments were performed in random order: intravenous infusion of 1) placebo, 2) low-dose atropine (5 micrograms.kg-.h-1), and 3) the CCK-A receptor antagonist loxiglumide (22 mumol.kg-.h-1). Atropine decreased postprandial outputs of HGL, pepsin, gastric acid, and HPL (P < 0.03) while slowing gastric emptying (P < 0.05). Loxiglumide markedly increased the secretion of HGL, pepsin, and acid while distinctly reducing HPL outputs and accelerating gastric emptying (P < 0.03). Plasma CCK and gastrin levels increased during loxiglumide infusion (P < 0.03). Atropine enhanced gastrin but not CCK release. Postprandial HGL, pepsin, and acid secretion are under positive cholinergic but negative CCK control, whereas HPL is stimulated by cholinergic and CCK mechanisms. We conclude that CCK and cholinergic mechanisms have an important role in the coordination of HGL and HPL secretion to optimize digestion of dietary lipids in humans. |
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Authors:
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J Borovicka; W Schwizer; C Mettraux; C Kreiss; B Remy; K Asal; J B Jansen; I Douchet; R Verger; M Fried |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 273 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-24 Completed Date: 1997-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G374-80 Citation Subset: IM |
Affiliation:
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Gastroenterology Department, Policlinique Médicale Universitaire, Lausanne, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholecystokinin / blood, pharmacology* Duodenum / metabolism Female Gastric Acid / metabolism Gastric Emptying Gastrins / blood Humans Lipase / metabolism* Male Pancreas / enzymology* Parasympathetic Nervous System / physiology* Stomach / enzymology* |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 9011-97-6/Cholecystokinin; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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