Document Detail

Regulation of functional differentiation of the placental villous syncytiotrophoblast by estrogen during primate pregnancy.
MedLine Citation:
PMID:  10503719     Owner:  NLM     Status:  MEDLINE    
By using the baboon as an in vivo model for the study of the endocrinology of human pregnancy, studies in the authors' laboratories have shown that the primate placenta is an estrogen target tissue and that estrogen, via interaction with the estrogen receptor, regulates functional differentiation of the syncytiotrophoblast, which is manifest as an upregulation of key components of the progesterone biosynthetic pathway and the metabolism of corticosteroids critical to placental-fetal development. Thus, estrogen exerts specific stimulatory effects on the receptor-mediated uptake of low density lipoprotein by, and expression of, the P-450 cholesterol side-chain cleavage enzyme within the syncytiotrophoblast, thereby promoting the production of progesterone. Concomitantly, there is an estrogen-dependent developmental regulation of the 11beta-hydroxysteroid dehydrogenase enzyme system in the syncytiotrophoblast, which enhances transplacental oxidation of maternal cortisol to cortisone and leads to maturation of the fetal hypothalamic pituitary adrenocortical axis late in gestation. Consequently, estrogen has a central, integrative role in modulating the dialogue and signaling system operating between the placenta and fetus that results in the maintenance of pregnancy and the development of adrenocortical self-sufficiency that are essential for maturation of the fetus and neonatal survival after birth.
G J Pepe; E D Albrecht
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Steroids     Volume:  64     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-26     Completed Date:  1999-10-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  624-7     Citation Subset:  IM    
Department of Physiology, Eastern Virginia Medical School, Norfolk 23507, USA.
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MeSH Terms
11-beta-Hydroxysteroid Dehydrogenases
Cell Differentiation / physiology*
Estrogens / physiology*
Hydroxysteroid Dehydrogenases / metabolism
Pregnancy, Animal / physiology*
Primates / physiology*
Progesterone / biosynthesis
Trophoblasts / cytology*,  enzymology
Grant Support
Reg. No./Substance:
0/Estrogens; 57-83-0/Progesterone; EC 1.1.-/Hydroxysteroid Dehydrogenases; EC Dehydrogenases

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