Document Detail


Regulation and function of polyamines in African trypanosomes.
MedLine Citation:
PMID:  22192816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The polyamine biosynthetic pathway is an important drug target for the treatment of human African trypanosomiasis (HAT), raising interest in understanding polyamine function and their mechanism of regulation. Polyamine levels are tightly controlled in mammalian cells, but similar regulatory mechanisms appear absent in trypanosomes. Instead trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), which catalyzes a key step in the biosynthesis of the polyamine spermidine, is activated by dimerization with an inducible protein termed prozyme. Prozyme is an inactive paralog of the active AdoMetDC enzyme that evolved by gene duplication and is found only in the trypanosomatids. In Trypanosoma brucei, AdoMetDC activity appears to be controlled by regulation of prozyme protein levels, potentially at the translational level.
Authors:
Erin Willert; Margaret A Phillips
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-12-20
Journal Detail:
Title:  Trends in parasitology     Volume:  28     ISSN:  1471-5007     ISO Abbreviation:  Trends Parasitol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-05-01     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  100966034     Medline TA:  Trends Parasitol     Country:  England    
Other Details:
Languages:  eng     Pagination:  66-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adenosylmethionine Decarboxylase / metabolism
Animals
Biosynthetic Pathways / drug effects
Gene Expression Regulation, Enzymologic
Humans
Polyamines / metabolism*
Trypanocidal Agents / pharmacology,  therapeutic use
Trypanosoma brucei brucei / drug effects,  enzymology,  physiology*
Trypanosomiasis, African / drug therapy
Chemical
Reg. No./Substance:
0/Polyamines; 0/Trypanocidal Agents; EC 4.1.1.50/Adenosylmethionine Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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