| Regulation and function of T1/ST2 expression on CD4+ T cells: induction of type 2 cytokine production by T1/ST2 cross-linking. | |
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MedLine Citation:
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PMID: 11207266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The orphan receptor T1/ST2, a member of the IL-1R family, is preferentially expressed on the surface of murine Th2 cells. In this study, we analyzed the kinetics and function of T1/ST2 expression on Th2 cells in vitro. Whereas naive CD4(+) cells did not express T1/ST2, most CD4(+) cells became T1/ST2(+) upon repeated antigenic stimulation under Th2-polarizing conditions. Flow cytometric analyses revealed that the kinetics of T1/ST2 expression on Th2 cells was delayed compared with the kinetics of type 2 cytokine production. Exogenous IL-6, IL-5, IL-1, and TNF-alpha enhanced the expression of T1/ST2 on Th2 cells, and IL-6 was by far most effective in this regard. However, the expression of T1/ST2 did not depend on the presence of IL-6 and was also detected in IL-6-deficient mice. Most important, cross-linking of T1/ST2 provided a costimulatory signal for Th2 but not Th1 cells and directly induced proliferation and type 2 cytokine production. Thus, T1/ST2 is not only a Th2 cell marker but also plays an important role in the activation of Th2 cells. |
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Authors:
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C Meisel; K Bonhagen; M Löhning; A J Coyle; J C Gutierrez-Ramos; A Radbruch; T Kamradt |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 166 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-14 Completed Date: 2001-04-26 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 3143-50 Citation Subset: AIM; IM |
Affiliation:
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Deutsches Rheumaforschungszentrum, Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / metabolism Cells, Cultured Cytokines / biosynthesis* Interleukin-4 / biosynthesis Interleukin-5 / pharmacology Interleukin-6 / pharmacology Kinetics Lymphocyte Activation Membrane Proteins* Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Muromonab-CD3 / pharmacology Protein Biosynthesis* Proteins / immunology*, metabolism, physiology Receptors, Interleukin Th2 Cells / immunology*, metabolism* Tumor Necrosis Factor-alpha / pharmacology Up-Regulation / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Cytokines; 0/Il1rl1 protein, mouse; 0/Interleukin-5; 0/Interleukin-6; 0/Membrane Proteins; 0/Muromonab-CD3; 0/Proteins; 0/Receptors, Interleukin; 0/Tumor Necrosis Factor-alpha; 207137-56-2/Interleukin-4 |
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