| Regulation of frontline antibody responses by innate immune signals. | |
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MedLine Citation:
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PMID: 22477522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T-cell-dependent pathway provides immunological memory but is relatively slow to occur. Thus, it must be integrated with a faster, T-cell-independent pathway for B-cell activation through CD40 ligand-like molecules that are released by innate immune cells in response to microbial products. Here, we discuss recent advances in our understanding of the interplay between the innate immune system and B cells, particularly "frontline" B cells located in the marginal zone of the spleen and in the intestine. |
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Authors:
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Alejo Chorny; Irene Puga; Andrea Cerutti |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Immunologic research Volume: 54 ISSN: 1559-0755 ISO Abbreviation: Immunol. Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-10-17 Completed Date: 2013-03-07 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 4-13 Citation Subset: IM |
Affiliation:
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Department of Medicine, The Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation* B-Lymphocytes / immunology* Humans Immunity, Innate* Intestinal Mucosa / immunology Spleen / immunology |
| Grant Support | |
ID/Acronym/Agency:
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P01 096187//PHS HHS; P01 AI061093/AI/NIAID NIH HHS; P01 AI61093/AI/NIAID NIH HHS; R01 AI057653/AI/NIAID NIH HHS; R01 AI057653-06/AI/NIAID NIH HHS; R01 AI074378/AI/NIAID NIH HHS; R01 AI074378/AI/NIAID NIH HHS; R01 AI074378-05/AI/NIAID NIH HHS; R01 AI074378-06/AI/NIAID NIH HHS; U01 AI095613/AI/NIAID NIH HHS; U01 AI095613-01/AI/NIAID NIH HHS; U01 AI095613-02/AI/NIAID NIH HHS; U01 AI95613/AI/NIAID NIH HHS; U19 AI096187/AI/NIAID NIH HHS |
| Comments/Corrections | |
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