| Regulation of food intake through hypothalamic signaling networks involving mTOR. | |
MedLine Citation:
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PMID: 18429698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To maintain normal activity, single cells must assure that their energy needs and utilization are continuously matched. Likewise, multicellular organisms must constantly coordinate energy intake and expenditure to maintain energy homeostasis. The brain, and the hypothalamus in particular, plays a critical role in integrating and coordinating several types of signals, including hormones and nutrients, to guarantee such homeostasis. Like single cells, the hypothalamus also profits from intracellular pathways known to work as fuel sensors to maintain energy balance. One such pathway is the mammalian target of rapamycin (mTOR). mTOR integrates different sensory inputs to regulate protein synthesis rates in individual cells, and it has recently been implicated in the central nervous system to regulate food intake and body weight as well. This review provides an overview of the role of hypothalamic intracellular fuel sensors in the overall control of energy balance and discusses the potential contribution of these fuel-sensing mechanisms to the metabolic dysregulation associated with obesity. |
Authors:
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Stephen C Woods; Randy J Seeley; Daniela Cota |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annual review of nutrition Volume: 28 ISSN: 0199-9885 ISO Abbreviation: Annu. Rev. Nutr. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-10-10 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8209988 Medline TA: Annu Rev Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 295-311 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA. woodssc@ucmail.uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Energy Intake
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physiology* Energy Metabolism / physiology* Homeostasis Humans Hypothalamus / metabolism, physiology* Obesity / etiology, metabolism Protein Kinases / metabolism, physiology* Signal Transduction* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.-/Protein Kinases; EC 2.7.1.-/mTOR protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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