Document Detail

Regulation of food intake through hypothalamic signaling networks involving mTOR.
MedLine Citation:
PMID:  18429698     Owner:  NLM     Status:  MEDLINE    
To maintain normal activity, single cells must assure that their energy needs and utilization are continuously matched. Likewise, multicellular organisms must constantly coordinate energy intake and expenditure to maintain energy homeostasis. The brain, and the hypothalamus in particular, plays a critical role in integrating and coordinating several types of signals, including hormones and nutrients, to guarantee such homeostasis. Like single cells, the hypothalamus also profits from intracellular pathways known to work as fuel sensors to maintain energy balance. One such pathway is the mammalian target of rapamycin (mTOR). mTOR integrates different sensory inputs to regulate protein synthesis rates in individual cells, and it has recently been implicated in the central nervous system to regulate food intake and body weight as well. This review provides an overview of the role of hypothalamic intracellular fuel sensors in the overall control of energy balance and discusses the potential contribution of these fuel-sensing mechanisms to the metabolic dysregulation associated with obesity.
Stephen C Woods; Randy J Seeley; Daniela Cota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  28     ISSN:  0199-9885     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-10-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-311     Citation Subset:  IM    
Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA.
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MeSH Terms
Energy Intake / physiology*
Energy Metabolism / physiology*
Hypothalamus / metabolism,  physiology*
Obesity / etiology,  metabolism
Protein Kinases / metabolism,  physiology*
Signal Transduction*
Reg. No./Substance:
EC 2.7.-/Protein Kinases; EC 2.7.1.-/mTOR protein

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