Document Detail


Regulation of food intake and body weight by cobalt porphyrins in animals.
MedLine Citation:
PMID:  2798429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cobalt-substituted protoporphyrin administered subcutaneously to normal adult rats elicited prompt decreases in food intake and sustained decreases in body weight. Repetitive parenteral administration of small doses of this synthetic heme analogue resulted in dose-related diminutions of carcass fat content without changes in carcass protein content. Direct injection of the compound into the third ventricle of the brain produced changes in food intake and body weight that were quantitatively similar to those observed after parenteral treatment but required only 1-2% of the parenteral dose. The effects of intracerebroventricularly administered cobalt protoporphyrin on body weight were dose-related and were not produced by inorganic cobalt, heme, and a number of other metal-substituted protoporphyrins. Differential body weights between control and treated animals persisted for at least 300 days after intracerebroventricular injections of a single dose (0.2 or 0.4 mumol/kg of body weight) of the compound. Similar effects were observed after subcutaneous administration of the metalloporphyrin to genetically obese Zucker (fa/fa) rats and normal and genetically obese (ob/ob) mice as well as chickens and dogs. Cobalt-substituted mesoporphyrin elicited comparable effects on food intake and body weight. The results of these studies define a new biological action of cobalt protoporphyrin and demonstrate that this and certain other cobalt porphyrins can act, at least in part, in the central nervous system to regulate appetite and to produce long-sustained diminutions in body weight and carcass content of fat in animals.
Authors:
R A Galbraith; A Kappas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  86     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-09     Completed Date:  1989-11-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7653-7     Citation Subset:  IM    
Affiliation:
Rockefeller University Hospital, New York, NY 10021.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects*
Cerebral Ventricles / drug effects,  physiology*
Cobalt / administration & dosage,  pharmacology*
Feeding Behavior / drug effects*
Injections, Intraventricular
Male
Porphyrins / pharmacology*
Protoporphyrins / administration & dosage,  pharmacology*
Rats
Rats, Inbred Strains
Reference Values
Grant Support
ID/Acronym/Agency:
ES-01055/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Porphyrins; 0/Protoporphyrins; 14325-03-2/cobaltiprotoporphyrin; 7440-48-4/Cobalt
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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