Document Detail


Regulation of focal adhesion dynamics by wnt5a signaling.
MedLine Citation:
PMID:  22218904     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Wnt5a is a representative ligand that activates the β-catenin-independent pathway of Wnt signaling in mammals. This pathway might be related to planar cell polarity signaling in Drosophila. Because reliable biochemical assays to measure Wnt5a pathway activity have not yet been established, we examined whether Wnt5a signaling stimulates focal adhesion turnover in migrating cells using live immunofluorescence imaging and immunocytochemical analysis. These assays demonstrated that the Wnt5a pathway cooperates with integrin signaling to regulate cell migration and adhesion through focal adhesion dynamics.
Authors:
Shinji Matsumoto; Akira Kikuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  839     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-27     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology & Biochemistry, Graduate School of Medicine, Faculty of Medicine, Osaka University, Osaka, Japan.
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