Document Detail

Regulation of fetal growth: consequences and impact of being born small.
MedLine Citation:
PMID:  18279787     Owner:  NLM     Status:  MEDLINE    
The first trimester of pregnancy is the time during which organogenesis takes place and tissue patterns and organ systems are established. In the second trimester the fetus undergoes major cellular adaptation and an increase in body size, and in the third trimester organ systems mature ready for extrauterine life. In addition, during that very last period of intrauterine life there is a significant increase in body weight. In contrast to the postnatal endocrine control of growth, where the principal hormones directly influencing growth are growth hormone (GH) and the insulin-like growth factors (IGFs) via the GH-IGF axis, fetal growth throughout gestation is constrained by maternal factors and placental function and is coordinated by growth factors. In general, growth disorders only become apparent postnatally, but they may well be related to fetal life. Thus, fetal growth always needs to be considered in the overall picture of human growth as well as in its metabolic development.
Primus-E Mullis; Paolo Tonella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  22     ISSN:  1521-690X     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  173-90     Citation Subset:  IM    
Division of Paediatric Endocrinology, University Children's Hospital, University of Bern, CH-3010 Bern, Switzerland.
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MeSH Terms
Chromosome Aberrations / embryology
Fetal Development*
Fetal Growth Retardation / metabolism*,  therapy
Growth Hormone
Hormones / metabolism
Infant, Newborn
Infant, Small for Gestational Age / growth & development*,  metabolism
Insulin / metabolism
Placental Hormones / metabolism
Somatomedins / metabolism
Reg. No./Substance:
0/Hormones; 0/Placental Hormones; 0/Somatomedins; 11061-68-0/Insulin; 9002-72-6/Growth Hormone

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