| Regulation of fatty acid metabolism and gluconeogenesis by growth hormone and insulin in sheep hepatocyte cultures. Effects of lactation and pregnancy. | |
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MedLine Citation:
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PMID: 2001235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary monolayer hepatocyte cultures derived from non-mated, pregnant and lactating sheep were used to investigate the interactions between the effects of growth hormone and insulin on (i) the partitioning of fatty acid metabolism between oxidation and esterification, and (ii) the rate of gluconeogenesis. In hepatocytes from lactating sheep the rates of gluconeogenesis, ketogenesis and very-low-density lipoprotein secretion were approx. 2-fold higher than in cells from non-mated or pregnant animals. There was no apparent difference in the rates of fatty acid uptake between the three groups of sheep cells. Growth hormone stimulated gluconeogenesis only in hepatocytes from non-mated sheep. It has no effect on the flux of fatty acid towards ketone body formation. Growth hormone inhibited intracellular accumulation of acylglycerol from exogenous fatty acid. Insulin alone had no such effect, but it blunted the effect of growth hormone when the two hormones were present together. The data suggest that major differences may exist between ruminants and non-ruminants in the response of liver metabolism both to lactation per se and to the effects of growth hormone and insulin. |
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Authors:
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N Emmison; L Agius; V A Zammit |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Biochemical journal Volume: 274 ( Pt 1) ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-04-08 Completed Date: 1991-04-08 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Affiliation:
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Hannah Research Institute, Ayr, Scotland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / drug effects Cells, Cultured Female Gluconeogenesis / drug effects* Growth Hormone / pharmacology* Insulin / pharmacology* Kinetics Lactation / metabolism* Liver / drug effects, metabolism* Palmitic Acid Palmitic Acids / metabolism* Pregnancy Pregnancy, Animal / metabolism* Reference Values Sheep |
| Chemical | |
Reg. No./Substance:
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0/Palmitic Acids; 11061-68-0/Insulin; 57-10-3/Palmitic Acid; 9002-72-6/Growth Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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