| Regulation of fatty acid and cholesterol synthesis: co-operation or competition? | |
| | |
MedLine Citation:
|
PMID: 14559068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fatty acids and sterols originally evolved symbiotically as structural components of cell membranes. In some respects, control of their biosynthetic pathways reflects their mutual interdependence in defining changes in the physicochemical properties of the membranes in response to the changing internal and external cellular environments. In some tissues of higher animals, however, cholesterol and fatty acids have multifunctional roles. In particular, the liver synthesizes these lipids for export as multimolecular complexes in the form of micellar bile components and lipoproteins. Intrahepatic fatty acid and cholesterol synthesis is dependent upon the balance between hepatic output of these complexes and dietary input of fat and cholesterol. Thus physiological control of these synthetic processes is often co-ordinated at both the transcriptional and post-translational levels. On the other hand, changes in flux through major metabolic pathways, particularly during physiological transitions and as a result of genetic manipulation, affects substrate availability for these pathways. Under these circumstances, regulation reflects a compensatory response to ensure that flux through the lipid pathways remains unchanged. These regulatory changes can best be interpreted in terms of a Metabolic Control Analysis approach. In summary, flux through the fatty acid and cholesterol pathways reflects (a) cellular demand for these lipids, (b) a variable availability of substrates, (c) a combination of (a) and (b). |
| | |
Authors:
|
Geoffrey F Gibbons |
Related Documents
:
|
465128 - Elastin--lipid interaction action in the arterial wall. part 1. extraction of elastin f... 9500688 - Accurate separation of biliary lipid aggregates requires the correct intermixed micella... 7086828 - Hypocholesterolemic and antiaggregatory properties of 2-hydroxytetronic acid redox anal... 1643098 - Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in ... 12419408 - Sour taste stimulation facilitates reflex swallowing from the pharynx and larynx in the... 12164478 - Drugs that inhibit mycolic acid biosynthesis in mycobacterium tuberculosis. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Progress in lipid research Volume: 42 ISSN: 0163-7827 ISO Abbreviation: Prog. Lipid Res. Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2003-10-15 Completed Date: 2004-02-10 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7900832 Medline TA: Prog Lipid Res Country: England |
Other Details:
|
Languages: eng Pagination: 479-97 Citation Subset: IM |
Affiliation:
|
Metabolic Research Laboratory, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Headington, OX3 7LJ, Oxford, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arteriosclerosis
/
metabolism CCAAT-Enhancer-Binding Proteins / metabolism Cell Membrane / metabolism* Cholesterol / biosynthesis* Cholesterol, Dietary / metabolism DNA-Binding Proteins / metabolism Fatty Acids / biosynthesis* Homeostasis Humans Hydroxymethylglutaryl CoA Reductases / metabolism Lipid Metabolism Liver / metabolism* Sterol Regulatory Element Binding Protein 1 Transcription Factors* |
| Chemical | |
Reg. No./Substance:
|
0/CCAAT-Enhancer-Binding Proteins; 0/Cholesterol, Dietary; 0/DNA-Binding Proteins; 0/Fatty Acids; 0/SREBF1 protein, human; 0/Sterol Regulatory Element Binding Protein 1; 0/Transcription Factors; 57-88-5/Cholesterol; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonizat...
Next Document: Membrane fluidity and the perception of environmental signals in cyanobacteria and plants.