Document Detail

Regulation of epididymal principal cell functions by basal cells: role of transient receptor potential (Trp) proteins and cyclooxygenase-1 (COX-1).
MedLine Citation:
PMID:  15109739     Owner:  NLM     Status:  MEDLINE    
The epithelia lining the epididymides of many species including the human are known to consist of several cell types. Among them, the principal cells are the most abundant and their functions most extensively studied. There are other cell types such as the narrow cells, clear cells, halo cells and basal cells which are scattered along the duct in lesser number. Although these minority cell types have not been studied to the same extent as the principal cells, it is conceivable that their presence are essential to the integrated functions of the epididymis. In the intact epididymis, basal cells can be seen adhering to the basement membrane forming close contact with the principal cells above them. Work in our laboratory has provided evidence that through local formation of prostaglandins, basal cells may regulate electrolyte and water transport by the principal cells. This regulatory process involves two proteins which are exclusively expressed by the basal cells. They are the transient receptor potential (Trp) proteins, which serve as transmembrane pathways for Ca(2+) influx, and cyclooxygenase 1 (COX-1), a key enzyme in the formation of prostaglandins. The role of the two proteins in the integrated functions of the basal cells as humoral regulators of principal cells is discussed.
G P H Leung; K H Cheung; C T Leung; M W Tsang; P Y D Wong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  216     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-27     Completed Date:  2004-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  5-13     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., China.
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MeSH Terms
Calcium Channels / genetics,  metabolism*
Cyclooxygenase 1
Cyclooxygenase Inhibitors / pharmacology
Epididymis / cytology*,  metabolism*
Epithelial Cells / cytology,  physiology*
Isoenzymes / metabolism*
Membrane Potentials / drug effects
Membrane Proteins / genetics,  metabolism*
Models, Biological
Prostaglandin-Endoperoxide Synthases / metabolism*
Reg. No./Substance:
0/Calcium Channels; 0/Cyclooxygenase Inhibitors; 0/Isoenzymes; 0/Membrane Proteins; EC 1; EC protein, human; EC Synthases

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