| Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2. | |
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MedLine Citation:
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PMID: 18347010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phosphatidylcholine transfer protein (PC-TP, also known as StarD2) is a highly specific intracellular lipid binding protein with accentuated expression in oxidative tissues. Here we show that decreased plasma concentrations of glucose and free fatty acids in fasting PC-TP-deficient (Pctp(-/-)) mice are attributable to increased hepatic insulin sensitivity. In hyperinsulinemic-euglycemic clamp studies, Pctp(-/-) mice exhibited profound reductions in hepatic glucose production, gluconeogenesis, glycogenolysis, and glucose cycling. These changes were explained in part by the lack of PC-TP expression in liver per se and in part by marked alterations in body fat composition. Reduced respiratory quotients in Pctp(-/-) mice were indicative of preferential fatty acid utilization for energy production in oxidative tissues. In the setting of decreased hepatic fatty acid synthesis, increased clearance rates of dietary triglycerides and increased hepatic triglyceride production rates reflected higher turnover in Pctp(-/-) mice. Collectively, these data support a key biological role for PC-TP in the regulation of energy substrate utilization. |
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Authors:
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Erez F Scapa; Alessandro Pocai; Michele K Wu; Roger Gutierrez-Juarez; Lauren Glenz; Keishi Kanno; Hua Li; Sudha Biddinger; Linda A Jelicks; Luciano Rossetti; David E Cohen |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2008-03-17 |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 22 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2008-08-12 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
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Languages: eng Pagination: 2579-90 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Carrier Proteins / metabolism Cell Culture Techniques Crosses, Genetic Energy Metabolism Fatty Acids, Nonesterified / blood Gene Expression Regulation Glucose Clamp Technique Glucose Tolerance Test Hepatocytes / cytology, physiology Insulin / physiology* Lipids / physiology Liver / physiology* Mice Mice, Knockout Phospholipid Transfer Proteins / deficiency*, genetics, metabolism* RNA, Messenger / genetics Triglycerides / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK-48873/DK/NIDDK NIH HHS; DK-56626/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Carrier Proteins; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Lipids; 0/Phospholipid Transfer Proteins; 0/RNA, Messenger; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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