Document Detail


Regulation of energy expenditure in brown adipose tissue.
MedLine Citation:
PMID:  2999014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The endocrinological and biochemical mechanisms controlling energy expenditure in brown adipose tissue at the cellular as well as at the total tissue levels are briefly reviewed. Thermogenesis in brown adipose tissue is principally controlled by the activity of hormone-sensitive lipases that represent the 'flux-generating' step in the stimulus-calorigenesis sequence. Long chain fatty acids are the physiological messengers regulating mitochondrial respiration. Agents stimulating brown adipocyte lipolysis (catecholamines, glucagon, methylxanthines) also stimulate respiration, and conversely, agents inhibiting lipolysis (adrenergic antagonists, insulin, prostaglandins) also inhibit respiration. This indicates that lipolysis and respiration are functionally coupled in brown adipose tissue. On the other hand, brown adipose tissue thermogenic capacity increases during cold acclimation or adaptation to hyperphagia. Brown adipocyte proliferation and differentiation from precursor cells (interstitial cells and brown preadipocytes) represent the fundamental phenomena explaining the increase capacity of cold acclimated and/or hyperphagic animals for responding calorigenically to catecholamines. Physiological situations associated with a stimulation of energy expenditure and a negative energy balance (cold acclimation, exercise training, caffeine consumption) generally induce a stimulation of adipocyte proliferation in brown adipose tissue that is accompanied by a simultaneous inhibition of cell proliferation in white adipose tissue. The physiological significance of these metabolic adaptations is to modulate the capacity of homeothermic animals for energy expenditure in accordance with energy requirements.
Authors:
L J Bukowiecki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of obesity     Volume:  9 Suppl 2     ISSN:  -     ISO Abbreviation:  Int J Obes     Publication Date:  1985  
Date Detail:
Created Date:  1986-01-21     Completed Date:  1986-01-21     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  7703240     Medline TA:  Int J Obes     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / cytology
Adipose Tissue, Brown / metabolism*
Animals
Body Temperature Regulation
Bucladesine / pharmacology
Caffeine / pharmacology
Cold Temperature
Dose-Response Relationship, Drug
Energy Metabolism*
Female
Hyperphagia / physiopathology
Models, Biological
Norepinephrine / pharmacology
Oxygen Consumption / drug effects
Palmitic Acid
Palmitic Acids / pharmacology
Physical Exertion
Propranolol / pharmacology
Rats
Rats, Inbred Strains
Temperature
Theophylline / pharmacology
Chemical
Reg. No./Substance:
0/Palmitic Acids; 2V16EO95H1/Palmitic Acid; 3G6A5W338E/Caffeine; 63X7MBT2LQ/Bucladesine; 9Y8NXQ24VQ/Propranolol; C137DTR5RG/Theophylline; X4W3ENH1CV/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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