| Regulation of endothelin-1 at rest and during a short steady-state exercise in 21 COPD patients. | |
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MedLine Citation:
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PMID: 9918748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin-1 (ET-1) is a vasoconstrictive peptide which may play a relevant role in the pathogenesis of pulmonary hypertension (PH) in COPD patients. We assessed the correlations of plasmatic ET-1 levels with pulmonary function data, arterial blood gases and pulmonary haemodynamics in 21 COPD patients with moderate to severe airway obstruction (FEV1: 1.19+/-0.49 l, mean+/-SD). There were 11 hypoxemic patients (PaO2 <65 mmHg). Six patients had resting PH (mean pulmonary artery pressure >/=20 mmHg). Eight patients had exercising PH (PAP >/=30 mmHg) during a short (6 min) 30 W steady state exercise. At rest, arterial ET-1 levels were significantly higher in COPD patients with hypoxemia when compared to those without hypoxemia (16.6+/-2.7 vs. 12.5+/-3.9 pM/l, P=0.02) and in COPD patients with PH when compared to those without PH (16.5+/-3.4 vs. 13+/-3.9 pM/l, P=0.04). Resting arterial ET-1 levels were negatively correlated with PaO2 (r=-0.45, P=0.05). At rest, the differences between mixed venous and arterial ET-1 levels were positively correlated with FEV1 (r=0.54, P=0.024). At exercise, the mean arterial ET-1 level was not significantly different from the mean resting ET-1 level (13.8+/-3.4 vs. 13.3+/-4 p M/l, NS). There were eight COPD patients who had decreasing arterial ET-1 levels between rest and the end of a 6 min exercise, and six COPD patients who had increasing arterial ET-1 levels. These variations of arterial systemic ET-1 levels from rest to exercise were negatively correlated with FEV1 (r=-0.66, P=0.01). We conclude that in COPD patients (1) at rest, arterial ET-1 levels are increased in hypoxemia or pulmonary hypertension and (2) at rest or during exercise, the turn-over of ET-1 may be dependent of the degree of the bronchial obstruction. |
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Authors:
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M Faller; R Kessler; R Sapin; A Chaouat; M Ehrhart; A Ducoloné; E Weitzenblum |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pulmonary pharmacology & therapeutics Volume: 11 ISSN: 1094-5539 ISO Abbreviation: Pulm Pharmacol Ther Publication Date: 1998 Apr-Jun |
Date Detail:
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Created Date: 1999-02-22 Completed Date: 1999-02-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9715279 Medline TA: Pulm Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 151-7 Citation Subset: IM |
Copyright Information:
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Copyright 1998 Academic Press. |
Affiliation:
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Service de Pneumologie, Hôpital de Hautepierre, Strasbourg, Cedex, 67098, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anoxia / physiopathology Bronchoconstriction Endothelin-1 / biosynthesis* Exercise / physiology* Female Hemodynamics Humans Hypertension, Pulmonary / etiology, physiopathology* Lung / blood supply, physiology Lung Diseases, Obstructive / complications, physiopathology* Male Middle Aged Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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