Document Detail

Regulation of endothelin-1 at rest and during a short steady-state exercise in 21 COPD patients.
MedLine Citation:
PMID:  9918748     Owner:  NLM     Status:  MEDLINE    
Endothelin-1 (ET-1) is a vasoconstrictive peptide which may play a relevant role in the pathogenesis of pulmonary hypertension (PH) in COPD patients. We assessed the correlations of plasmatic ET-1 levels with pulmonary function data, arterial blood gases and pulmonary haemodynamics in 21 COPD patients with moderate to severe airway obstruction (FEV1: 1.19+/-0.49 l, mean+/-SD). There were 11 hypoxemic patients (PaO2 <65 mmHg). Six patients had resting PH (mean pulmonary artery pressure >/=20 mmHg). Eight patients had exercising PH (PAP >/=30 mmHg) during a short (6 min) 30 W steady state exercise. At rest, arterial ET-1 levels were significantly higher in COPD patients with hypoxemia when compared to those without hypoxemia (16.6+/-2.7 vs. 12.5+/-3.9 pM/l, P=0.02) and in COPD patients with PH when compared to those without PH (16.5+/-3.4 vs. 13+/-3.9 pM/l, P=0.04). Resting arterial ET-1 levels were negatively correlated with PaO2 (r=-0.45, P=0.05). At rest, the differences between mixed venous and arterial ET-1 levels were positively correlated with FEV1 (r=0.54, P=0.024). At exercise, the mean arterial ET-1 level was not significantly different from the mean resting ET-1 level (13.8+/-3.4 vs. 13.3+/-4 p M/l, NS). There were eight COPD patients who had decreasing arterial ET-1 levels between rest and the end of a 6 min exercise, and six COPD patients who had increasing arterial ET-1 levels. These variations of arterial systemic ET-1 levels from rest to exercise were negatively correlated with FEV1 (r=-0.66, P=0.01). We conclude that in COPD patients (1) at rest, arterial ET-1 levels are increased in hypoxemia or pulmonary hypertension and (2) at rest or during exercise, the turn-over of ET-1 may be dependent of the degree of the bronchial obstruction.
M Faller; R Kessler; R Sapin; A Chaouat; M Ehrhart; A Ducoloné; E Weitzenblum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  11     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:    1998 Apr-Jun
Date Detail:
Created Date:  1999-02-22     Completed Date:  1999-02-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Academic Press.
Service de Pneumologie, Hôpital de Hautepierre, Strasbourg, Cedex, 67098, France.
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MeSH Terms
Anoxia / physiopathology
Endothelin-1 / biosynthesis*
Exercise / physiology*
Hypertension, Pulmonary / etiology,  physiopathology*
Lung / blood supply,  physiology
Lung Diseases, Obstructive / complications,  physiopathology*
Middle Aged
Respiratory Function Tests
Reg. No./Substance:

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