Document Detail


Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration.
MedLine Citation:
PMID:  8214047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stable isotope tracers and indirect calorimetry were used to evaluate the regulation of endogenous fat and glucose metabolism in relation to exercise intensity and duration. Five trained subjects were studied during exercise intensities of 25, 65, and 85% of maximal oxygen consumption (VO2max). Plasma glucose tissue uptake and muscle glycogen oxidation increased in relation to exercise intensity. In contrast, peripheral lipolysis was stimulated maximally at the lowest exercise intensity, and fatty acid release into plasma decreased with increasing exercise intensity. Muscle triglyceride lipolysis was stimulated only at higher intensities. During 2 h of exercise at 65% VO2max plasma-derived substrate oxidation progressively increased over time, whereas muscle glycogen and triglyceride oxidation decreased. In recovery from high-intensity exercise, although the rate of lipolysis immediately decreased, the rate of release of fatty acids into plasma increased, indicating release of fatty acids from previously hydrolyzed triglycerides. We conclude that, whereas carbohydrate availability is regulated directly in relation to exercise intensity, the regulation of lipid metabolism seems to be more complex.
Authors:
J A Romijn; E F Coyle; L S Sidossis; A Gastaldelli; J F Horowitz; E Endert; R R Wolfe
Related Documents :
18948447 - Fluid and electrolyte supplementation after prolonged moderate-intensity exercise enhan...
2917917 - Operation everest ii: muscle energetics during maximal exhaustive exercise.
402347 - Cardiac glycogen repletion after exercise: influence of synthase and glucose 6-phosphate.
3308817 - Adrenal hormones enhance glycogenolysis in nonexercising muscle during exercise.
16640467 - Usability of the remote console for virtual reality telerehabilitation: formative evalu...
6246187 - Synaptic relationships of the cerebral giant cells with motoneurones in the feeding sys...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  265     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-11-23     Completed Date:  1993-11-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E380-91     Citation Subset:  IM    
Affiliation:
Metabolism Unit, Shriners Burns Institute, University of Texas Medical Branch, Galveston 77550.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / analysis*
Calorimetry, Indirect
Catecholamines / blood
Deuterium
Fatty Acids, Nonesterified / blood
Glycerol / blood
Humans
Kinetics
Lipids / blood*
Oxidation-Reduction
Oxygen Consumption
Physical Exertion*
Time Factors
Grant Support
ID/Acronym/Agency:
DK-378717/DK/NIDDK NIH HHS; GCRC-00073//PHS HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Catecholamines; 0/Fatty Acids, Nonesterified; 0/Lipids; 56-81-5/Glycerol; 7782-39-0/Deuterium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vitro lipid synthesis in human adipose tissue from three abdominal sites.
Next Document:  Regulation of glucose transporter and hexokinase II expression in tissues of diabetic rats.