Document Detail


Regulation and control of myosin-I by the motor and light chain-binding domains.
MedLine Citation:
PMID:  23200340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conservation in the motor and light chain-binding domains (LCBDs) of these myosins, recent studies have revealed surprising diversity of function and regulation arising from isoform-specific differences in these domains. Here we review the regulation of myosin-I function and localization by the motor and LCBDs.
Authors:
Michael J Greenberg; E Michael Ostap
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-11-29
Journal Detail:
Title:  Trends in cell biology     Volume:  23     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-07-18     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  81-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Actins / chemistry
Adenosine Triphosphatases / chemistry
Adenosine Triphosphate / chemistry
Animals
Binding Sites
Biomechanical Phenomena
Cell Membrane / chemistry*
Humans
Mechanotransduction, Cellular*
Myosin Type I / chemistry*
Protein Binding
Protein Interaction Mapping
Protein Isoforms / chemistry
Protein Structure, Tertiary
Protein Transport
Grant Support
ID/Acronym/Agency:
F32 GM097889/GM/NIGMS NIH HHS; F32 GM097889/GM/NIGMS NIH HHS; P01 GM087253/GM/NIGMS NIH HHS; P01 GM087253/GM/NIGMS NIH HHS; R01 GM057247/GM/NIGMS NIH HHS; T32 AR053461/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Actins; 0/Protein Isoforms; 8L70Q75FXE/Adenosine Triphosphate; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/Myosin Type I; EC 3.6.1.3/MYO1C protein, human
Comments/Corrections

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