Document Detail


Regulation of clones responding to dextran B1355S. II. Response of T-dependent and T-independent precursors.
MedLine Citation:
PMID:  6161158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The existence of precursors for TI and TD alpha 1 leads to 3 dextran antigens in BALB/c mice was demonstrated. A T-dependent dextran antigen was prepared by coupling dextran B1355S to hemocyanin and subsequent digestion with dextranase. The PFC response of BALB/c mice primed with hemocyanin to dextran-hemocyanin was found to be 8 times higher than in unprimed animals. The splenic focus assay was adapted for the analysis of precursors responding to T-dependent and T-independent dextran antigens. Pretreatment of recipients with anti-thymocyte serum abolished the response in fragment cultures to dextran-hemocyanin but did not affect the response to dextran B1355S. The frequencies of precursors in the adult BALB/c mouse responding to dextran and dextran-hemocyanin were determined by limiting dilution analysis. The frequency of T-dependent precursors was found to be almost 3 times greater than the frequency of T-independent precursors.
Authors:
R Ward; H Kohler
Related Documents :
18713728 - Mice deficient in the cxcr2 ligand, cxcl1 (kc/gro-alpha), exhibit increased susceptibil...
15082588 - Is the mucosal route of administration essential for probiotic function? subcutaneous a...
20084048 - Inflammation driven by overexpression of the hypoglycosylated abnormal mucin 1 (muc1) l...
9062998 - A mouse model of human familial adenomatous polyposis.
9760168 - Interferon-gamma variants with deletions in the ab surface loop--flexibility is a criti...
8124298 - Studies on lymphocyte characteristics in patients with homozygous alpha 1-proteinase in...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  126     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  146-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Specificity
Antigens
B-Lymphocytes / cytology
Cell Differentiation
Cells, Cultured
Clone Cells / immunology
Dextrans / immunology*
Female
Linkage (Genetics)
Male
Mice
Mice, Inbred BALB C
Rabbits
T-Lymphocytes / immunology*
Grant Support
ID/Acronym/Agency:
AI-11080/AI/NIAID NIH HHS; GM 07183/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fc (IgG) receptors on rat basophilic leukemia cells.
Next Document:  Idiotypic analysis of anti-GAT antibodies. VIII. Comparison of interstrain and allotype-associated i...