Document Detail

Regulation of circadian locomotor rhythm by neuropeptide Y-like system in Drosophila melanogaster.
MedLine Citation:
PMID:  23614491     Owner:  NLM     Status:  Publisher    
Circadian rhythms in behaviour and physiology exist widely in animals, plants, fungi and cyanobacteria. Although much work has been carried out to characterize the endogenous clock circuit, the output signals coupling the circadian pacemaker to behaviour and physiology remain elusive. Here, we show that neuropeptide F (NPF), a homologue of mammalian neuropeptide Y, and its G protein-coupled receptor NPFR1 regulate the locomotor rhythm in Drosophila melanogaster. Flies with loss of function in NPF or NPFR1 were unable to ramp up their activity before lights off under light : dark (LD) cycles, and oscillations in npf/NPF and npfr1/NPFR1 were found to correlate temporally with the locomotor rhythm. Furthermore, NPF is expressed in clock neurones including dorsolateral neurones (LNd s) and ventrolateral neurones (LNv s), whereas NPFR1 is expressed in dorsal neurone 1 (DN1) and LNd s. These results show that NPF signalling is involved in the circadian locomotor rhythm in LD cycles.
C He; X Cong; R Zhang; D Wu; C An; Z Zhao
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-25
Journal Detail:
Title:  Insect molecular biology     Volume:  -     ISSN:  1365-2583     ISO Abbreviation:  Insect Mol. Biol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9303579     Medline TA:  Insect Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Royal Entomological Society.
College of Agriculture and Biotechnology, China Agricultural University, Beijing, China.
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