Document Detail

Regulation of circadian clocks by redox homeostasis.
MedLine Citation:
PMID:  23861436     Owner:  NLM     Status:  MEDLINE    
Living organisms possess biological clocks that resonate with environmental cycles in light, temperature, and food availability. Recently, circadian oscillations in the redox state of peroxiredoxin have been described as an additional non-transcriptional timekeeping mechanism. Of note, this redox cycle is conserved in both prokaryotes and eukaryotes. How the classical "transcription-translation feedback loop" model and this redox oscillation are related is still poorly understood. In this minireview, we describe the most recent evidence pointing to cross-talk between the circadian clock and the redox status of the cell.
Alessandra Stangherlin; Akhilesh B Reddy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-07-16
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  288     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-16     Completed Date:  2013-12-17     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26505-11     Citation Subset:  IM    
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MeSH Terms
Circadian Clocks / physiology*
Circadian Rhythm
Gene Expression Regulation, Enzymologic*
Hydrogen Peroxide / chemistry
Oxygen / chemistry
Peroxiredoxins / chemistry
Signal Transduction
Thioredoxin-Disulfide Reductase / chemistry*
Thioredoxins / chemistry
Grant Support
083643/Z/07/Z//Wellcome Trust; 100333//Wellcome Trust; //Medical Research Council
Reg. No./Substance:
52500-60-4/Thioredoxins; BBX060AN9V/Hydrogen Peroxide; EC; EC Reductase; S88TT14065/Oxygen

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