Document Detail


Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice.
MedLine Citation:
PMID:  23536474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: This study suggests that a CYP7A1/SREBP2/miR-33a axis plays a critical role in regulation of hepatic cholesterol, bile acid, and fatty acid synthesis. Antagonism of miR-33a may be a potential strategy to increase bile acid synthesis to maintain lipid homeostasis and prevent nonalcoholic fatty liver disease, diabetes, and obesity.
Authors:
Tiangang Li; Jessica M Francl; Shannon Boehme; John Y L Chiang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-07-31
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-02     Completed Date:  2014-02-13     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1111-21     Citation Subset:  IM    
Copyright Information:
© 2013 by the American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Acetyl Coenzyme A / metabolism
Animals
Bile Acids and Salts / metabolism*
Cholesterol / metabolism*
Cholesterol 7-alpha-Hydroxylase / genetics,  metabolism*
Homeostasis / physiology*
Lipid Metabolism / physiology
Liver / metabolism
Male
Mice
Mice, Knockout
Mice, Transgenic
MicroRNAs / metabolism*
Models, Animal
RNA, Messenger / metabolism
Signal Transduction / physiology*
Sterol Regulatory Element Binding Protein 2 / metabolism*
Grant Support
ID/Acronym/Agency:
F32 DK096784/DK/NIDDK NIH HHS; R01 DK044442/DK/NIDDK NIH HHS; R01DK044442/DK/NIDDK NIH HHS; R37 DK058379/DK/NIDDK NIH HHS; R37DK058379/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/MicroRNAs; 0/Mirn33 microRNA, mouse; 0/RNA, Messenger; 0/Srebf2 protein, mouse; 0/Sterol Regulatory Element Binding Protein 2; 72-89-9/Acetyl Coenzyme A; 97C5T2UQ7J/Cholesterol; EC 1.14.13.17/Cholesterol 7-alpha-Hydroxylase; EC 1.14.13.17/Cyp7a1 protein, mouse
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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