Document Detail

Regulation of cholesterol absorption by phytosterols.
MedLine Citation:
PMID:  17045075     Owner:  NLM     Status:  MEDLINE    
Phytosterols are chemical homologs of cholesterol that are found in most plant foods and are particularly abundant in vegetable oils and whole grains. They interfere with the micellar solubilization of cholesterol in the intestine and reduce the efficiency of cholesterol absorption. The net absorption of phytosterols themselves is very small and most clinical studies suggest that consumption is safe. Phytosterols naturally present in foods appear to be bioactive, but many commercial phytosterol supplements are comprised of purified crystals with limited bioavailability. Proper formulation to improve bioavailability is critical for phytosterol supplements. Phytosterols appear to be quantitatively as important to cholesterol lowering as reducing saturated fat consumption, and they provide an additional tool for regulation of circulating cholesterol through lifestyle changes.
Richard E Ostlund; Xiaobo Lin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  8     ISSN:  1523-3804     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-18     Completed Date:  2007-01-11     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  487-91     Citation Subset:  IM    
Division of Endocrinology, Metabolism and Lipid Research, Box 8127, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
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MeSH Terms
Absorption / drug effects
Cholesterol / metabolism*
Hypercholesterolemia / drug therapy*,  metabolism
Phytosterols / therapeutic use*
Treatment Outcome
Grant Support
R01-50420//PHS HHS
Reg. No./Substance:
0/Phytosterols; 57-88-5/Cholesterol

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