Document Detail


Regulation of cholesterol 7 alpha-hydroxylase by different effectors.
MedLine Citation:
PMID:  8891849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cholesterol degradation to bile acids represents 50% of total elimination of cholesterol from the body each day. Cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase catalyze initial steps in the neutral and acidic pathways, respectively. Both enzymes were recently cloned and sequenced, and hence the molecular basis of their regulation could be studied. In the rat, cholesterol 7 alpha-hydroxylase is regulated by three classes of effector molecules: a) hydrophobic (but not hydrophilic) bile acids, b) cholesterol, and c) hormones (glucocorticoids plus thyroxine, glucagon and insulin). Most studies presented so far indicate that regulation of cholesterol 7 alpha-hydroxylase probably occurs at the level of gene transcription. Sterol 27-hydroxylase, a mitochondrial P-450 enzyme, appears to be regulated by hydrophobic bile acids, but to a lesser extent than cholesterol 7 alpha-hydroxylase. The contribution of this acidic pathway to total bile acid synthesis is not known but it appears to be more significant than previously thought.
Authors:
Z R Vlahcevic
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Italian journal of gastroenterology     Volume:  28     ISSN:  0392-0623     ISO Abbreviation:  Ital J Gastroenterol     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1997-01-31     Completed Date:  1997-01-31     Revised Date:  2012-01-30    
Medline Journal Info:
Nlm Unique ID:  8000544     Medline TA:  Ital J Gastroenterol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  337-9     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Virginia Commonwealth University, Richmond 23298, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / metabolism*
Cholesterol / metabolism*
Cholesterol 7-alpha-Hydroxylase / metabolism*
Cytochrome P-450 CYP27A1
Cytochrome P-450 Enzyme System / metabolism
Hormones / metabolism*
Humans
Rats
Steroid Hydroxylases / metabolism
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Hormones; 57-88-5/Cholesterol; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.-/Cytochrome P-450 CYP27A1; EC 1.14.-/Steroid Hydroxylases; EC 1.14.13.15/CYP27A1 protein, human; EC 1.14.13.17/Cholesterol 7-alpha-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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