Document Detail

Regulation of cellular differentiation and apoptosis by fatty acids and their metabolites.
MedLine Citation:
PMID:  12749359     Owner:  NASA     Status:  MEDLINE    
We have reviewed the literature regarding the effects of fatty acids and their metabolites on cellular differentiation and apoptosis. Results obtained in different studies have been variable, but some generalizations can be made. Differentiation was increased by incubation of cells with arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), or leukotriene D4 (LTD4). Effects of these agents on differentiation could be magnified with the simultaneous addition of other differentiation-inducing agents like dimethylsulfoxide or retinoic acid. AA and gamma-linolenic acid increased apoptosis while the effects of n-3 fatty acids (EPA and DHA) and of eicosanoids varied from stimulation to inhibition. These inconsistencies are attributed to the differences in methods used to evaluate differentiation and apoptosis, concentrations of fatty acids and serum, exposure time and the cell models used. Studies using the physiological concentrations of the fatty acids and standardized experimental conditions need to be conducted to establish effects of fatty acids and their metabolites on these cellular processes.
I L Rudolph; D S Kelley; K C Klasing; K L Erickson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition research (New York, N.Y.)     Volume:  21     ISSN:  0271-5317     ISO Abbreviation:  Nutr Res     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2003-05-15     Completed Date:  2003-05-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8303331     Medline TA:  Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381-93     Citation Subset:  S    
Copyright Information:
Published by Elsevier Science Inc. All rights reserved.
Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California, Davis, CA 95616, USA.
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MeSH Terms
Apoptosis / physiology*
Arachidonic Acid / physiology
Cell Differentiation / physiology*
Fatty Acids / metabolism,  physiology*
Leukotrienes / physiology
Myeloid Cells / physiology
Prostaglandins / physiology
Reg. No./Substance:
0/Fatty Acids; 0/Leukotrienes; 0/Prostaglandins; 506-32-1/Arachidonic Acid

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