| Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. | |
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MedLine Citation:
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PMID: 11891119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phosphatidylinositol 3-kinase lipid products and the Rho GTPases play a central role in transmitting information from chemotactic receptors to the effectors of cell polarity, and recent advances in the field have allowed us to understand these roles more clearly. Emergent properties of positive and negative regulation of these molecules may account for the establishment of cell polarity during chemotaxis for a wide range of cells from Dictyostelium to fibroblasts to neutrophils. |
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Authors:
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Orion D Weiner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in cell biology Volume: 14 ISSN: 0955-0674 ISO Abbreviation: Curr. Opin. Cell Biol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-03-13 Completed Date: 2002-07-26 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 196-202 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue/C-1, 502, Boston, MA 02115, USA. orion_weiner@hms.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism* Animals Cell Polarity / physiology* Chemotaxis / physiology* Humans Lysophospholipids* Platelet-Derived Growth Factor / metabolism Signal Transduction / physiology* Sphingosine / analogs & derivatives*, metabolism rho GTP-Binding Proteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM027800-27/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lysophospholipids; 0/Platelet-Derived Growth Factor; 123-78-4/Sphingosine; 26993-30-6/sphingosine 1-phosphate; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 3.6.5.2/rho GTP-Binding Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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