Document Detail


Regulation of cell pH by ambient bicarbonate, carbon dioxide tension, and pH in the rabbit proximal convoluted tubule.
MedLine Citation:
PMID:  3123519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSIONS: (a) Steady-state cell pH changes in response to changes in extracellular [HCO3] and PCO2 are quantitatively similar for a given change in extracellular pH; (b) the rate of the basolateral Na/(HCO3)3 cotransporter is a more important determinant of cell pH than the rate of the apical membrane mechanism(s); (c) cell pH defense against acute changes in PCO2 depends on the basolateral Na/(HCO3)3 cotransporter (acid and alkaline loads) and the luminal Na/H antiporter (acid loads).
Authors:
R Krapf; C A Berry; R J Alpern; F C Rector
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  81     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-18     Completed Date:  1988-03-18     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / pharmacology
Amiloride / pharmacology
Animals
Bicarbonates / physiology*
Carbon Dioxide / physiology*
Fluoresceins / diagnostic use
Hydrogen-Ion Concentration*
Kidney Tubules, Proximal / cytology,  physiology*
Rabbits
Grant Support
ID/Acronym/Agency:
DK-01229/DK/NIDDK NIH HHS; DK-26142/DK/NIDDK NIH HHS; DK-27945/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Bicarbonates; 0/Fluoresceins; 142M471B3J/Carbon Dioxide; 27816-59-7/4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 7DZO8EB0Z3/Amiloride; 85138-49-4/2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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