Document Detail


Regulation of cell fate in the sensory epithelia of the inner ear.
MedLine Citation:
PMID:  17053809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sensory epithelia of the inner ear contain mechanosensory hair cells and non-sensory supporting cells. Both classes of cell are heterogeneous, with phenotypes varying both between and within epithelia. The specification of individual cells as distinct types of hair cell or supporting cell is regulated through intra- and extracellular signalling pathways that have been poorly understood. However, new methodologies have resulted in significant steps forward in our understanding of the molecular pathways that direct cells towards these cell fates.
Authors:
Matthew W Kelley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  7     ISSN:  1471-003X     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-20     Completed Date:  2007-01-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  837-49     Citation Subset:  IM    
Affiliation:
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 35 Convent Dr., Bethesda, Maryland 20892, USA. Kelleymt@nidcd.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology*
Cell Lineage / physiology*
Ear, Inner / cytology,  embryology*,  metabolism
Gene Expression Regulation, Developmental / physiology
Hair Cells, Auditory / cytology,  embryology*,  metabolism
Humans
Labyrinth Supporting Cells / cytology*,  metabolism
Nerve Growth Factors / genetics
Nerve Tissue Proteins / genetics
Signal Transduction / physiology
Chemical
Reg. No./Substance:
0/Nerve Growth Factors; 0/Nerve Tissue Proteins
Comments/Corrections
Erratum In:
Nat Rev Neurosci. 2007 Mar;8(3):239

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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