| Regulation of the cell cycle by protein phosphatase 2A in Saccharomyces cerevisiae. | |
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MedLine Citation:
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PMID: 16760309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Protein phosphatase 2A (PP2A) has long been implicated in cell cycle regulation in many different organisms. In the yeast Saccharomyces cerevisiae, PP2A controls cell cycle progression mainly through modulation of cyclin-dependent kinase (CDK) at the G(2)/M transition. However, CDK does not appear to be a direct target of PP2A. PP2A affects CDK activity through its roles in checkpoint controls. Inactivation of PP2A downregulates CDK by activating the morphogenesis checkpoint and, consequently, delays mitotic entry. Defects in PP2A also compromise the spindle checkpoint and predispose the cell to an error-prone mitotic exit. In addition, PP2A is involved in controlling the G(1)/S transition and cytokinesis. These findings suggest that PP2A functions in many stages of the cell cycle and its effect on cell cycle progression is pleiotropic. |
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Authors:
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Yu Jiang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Microbiology and molecular biology reviews : MMBR Volume: 70 ISSN: 1092-2172 ISO Abbreviation: Microbiol. Mol. Biol. Rev. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-08 Completed Date: 2006-08-03 Revised Date: 2012-04-23 |
Medline Journal Info:
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Nlm Unique ID: 9706653 Medline TA: Microbiol Mol Biol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 440-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. jiang@server.pharm.pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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physiology* Isoenzymes / genetics, metabolism Phosphoprotein Phosphatases / genetics, metabolism* Protein Phosphatase 2 Saccharomyces cerevisiae / genetics, physiology* Saccharomyces cerevisiae Proteins / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM068832/GM/NIGMS NIH HHS; R01 GM068832/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 0/Saccharomyces cerevisiae Proteins; EC 3.1.3.16/Phosphoprotein Phosphatases; EC 3.1.3.16/Protein Phosphatase 2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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