Document Detail


Regulation of the cell cycle by protein phosphatase 2A in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  16760309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protein phosphatase 2A (PP2A) has long been implicated in cell cycle regulation in many different organisms. In the yeast Saccharomyces cerevisiae, PP2A controls cell cycle progression mainly through modulation of cyclin-dependent kinase (CDK) at the G(2)/M transition. However, CDK does not appear to be a direct target of PP2A. PP2A affects CDK activity through its roles in checkpoint controls. Inactivation of PP2A downregulates CDK by activating the morphogenesis checkpoint and, consequently, delays mitotic entry. Defects in PP2A also compromise the spindle checkpoint and predispose the cell to an error-prone mitotic exit. In addition, PP2A is involved in controlling the G(1)/S transition and cytokinesis. These findings suggest that PP2A functions in many stages of the cell cycle and its effect on cell cycle progression is pleiotropic.
Authors:
Yu Jiang
Related Documents :
9872729 - Protein dephosphorylation and the intracellular control of the cell number.
21215309 - Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative s...
8763499 - How viral oncogenes make the cell cycle.
9018099 - 17beta-estradiol metabolites affect some regulators of the mcf-7 cell cycle.
9683889 - The plasmodium cell-cycle: facts and questions.
19687139 - Dynamic chromosome organization and protein localization coordinate the regulatory circ...
18068219 - Glial cells: old cells with new twists.
22064259 - Disseminated langerhan's cell histiocytosis: a case report and review of the literature.
9547299 - Microtubule-mediated centrosome motility and the positioning of cleavage furrows in mul...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Microbiology and molecular biology reviews : MMBR     Volume:  70     ISSN:  1092-2172     ISO Abbreviation:  Microbiol. Mol. Biol. Rev.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-08     Completed Date:  2006-08-03     Revised Date:  2012-04-23    
Medline Journal Info:
Nlm Unique ID:  9706653     Medline TA:  Microbiol Mol Biol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  440-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. jiang@server.pharm.pitt.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Cycle / physiology*
Isoenzymes / genetics,  metabolism
Phosphoprotein Phosphatases / genetics,  metabolism*
Protein Phosphatase 2
Saccharomyces cerevisiae / genetics,  physiology*
Saccharomyces cerevisiae Proteins / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
GM068832/GM/NIGMS NIH HHS; R01 GM068832/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Saccharomyces cerevisiae Proteins; EC 3.1.3.16/Phosphoprotein Phosphatases; EC 3.1.3.16/Protein Phosphatase 2
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Escherichia coli proteome: past, present, and future prospects.
Next Document:  Plant pathogen forensics: capabilities, needs, and recommendations.