Document Detail

Regulation of the cell cycle by protein phosphatase 2A in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  16760309     Owner:  NLM     Status:  MEDLINE    
Protein phosphatase 2A (PP2A) has long been implicated in cell cycle regulation in many different organisms. In the yeast Saccharomyces cerevisiae, PP2A controls cell cycle progression mainly through modulation of cyclin-dependent kinase (CDK) at the G(2)/M transition. However, CDK does not appear to be a direct target of PP2A. PP2A affects CDK activity through its roles in checkpoint controls. Inactivation of PP2A downregulates CDK by activating the morphogenesis checkpoint and, consequently, delays mitotic entry. Defects in PP2A also compromise the spindle checkpoint and predispose the cell to an error-prone mitotic exit. In addition, PP2A is involved in controlling the G(1)/S transition and cytokinesis. These findings suggest that PP2A functions in many stages of the cell cycle and its effect on cell cycle progression is pleiotropic.
Yu Jiang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Microbiology and molecular biology reviews : MMBR     Volume:  70     ISSN:  1092-2172     ISO Abbreviation:  Microbiol. Mol. Biol. Rev.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-08     Completed Date:  2006-08-03     Revised Date:  2012-04-23    
Medline Journal Info:
Nlm Unique ID:  9706653     Medline TA:  Microbiol Mol Biol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  440-9     Citation Subset:  IM    
Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
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MeSH Terms
Cell Cycle / physiology*
Isoenzymes / genetics,  metabolism
Phosphoprotein Phosphatases / genetics,  metabolism*
Protein Phosphatase 2
Saccharomyces cerevisiae / genetics,  physiology*
Saccharomyces cerevisiae Proteins / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Isoenzymes; 0/Saccharomyces cerevisiae Proteins; EC Phosphatases; EC Phosphatase 2

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