| Regulation of cardiac output during aldosterone-induced hypertension. | |
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MedLine Citation:
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PMID: 2632719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The classical haemodynamic transients of volume-loading hypertension have been difficult to demonstrate in aldosterone-induced hypertension. Because recent studies have shown that continuous whole-day measurements of cardiac output are superior to short-term recordings, we studied the transient haemodynamic effects of aldosterone-induced hypertension while monitoring arterial pressure and cardiac output (electromagnetic flow probe) continuously for 20 h a day. In six dogs maintained on a fixed sodium intake of 150 mmol/day, we infused aldosterone (12 micrograms/kg per day, intravenously) for 10 days. The aldosterone induced a progressive increase in mean arterial pressure, from a control value of 88 +/- 1 to 107 +/- 2 mmHg. Cardiac output increased progressively, reaching a peak average value on the 4th day of infusion of +14 +/- 5% above control, and remained slightly elevated throughout the infusion period. Total peripheral resistance increased slowly to a value averaging +13 +/- 4% above control. Therefore, our experiments show that aldosterone induces a primary increase in cardiac output followed by a secondary vasoconstriction, which is consistent with the classical transient haemodynamic effects of volume-loading hypertension. |
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Authors:
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J P Montani; H L Mizelle; T H Adair; A C Guyton |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 7 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-05-11 Completed Date: 1990-05-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S206-7 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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administration & dosage,
pharmacology* Animals Blood Pressure Monitors Cardiac Output / drug effects*, physiology Dogs Hemodynamics / drug effects, physiology Hypertension / chemically induced, physiopathology* Infusions, Intravenous Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL 11678/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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