Document Detail


Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway.
MedLine Citation:
PMID:  17182864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postnatal growth of the heart is primarily achieved through hypertrophy of individual myocytes. Cardiac growth observed in athletes represents adaptive or physiological hypertrophy, whereas cardiac growth observed in patients with hypertension or valvular heart diseases is called maladaptive or pathological hypertrophy. These two types of hypertrophy are morphologically, functionally, and molecularly distinct from each other. The serine/threonine protein kinase Akt is activated by various extracellular stimuli in a phosphatidylinositol-3 kinase-dependent manner and regulates multiple aspects of cellular functions including survival, growth and metabolism. In this review we will discuss the role of the Akt signaling pathway in the heart, focusing on the regulation of cardiac growth, contractile function, and coronary angiogenesis. How this signaling pathway contributes to the development of physiological/pathological hypertrophy and heart failure will also be discussed.
Authors:
Ichiro Shiojima; Kenneth Walsh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Genes & development     Volume:  20     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-21     Completed Date:  2007-01-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3347-65     Citation Subset:  IM    
Affiliation:
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA. shiojima@faculty.chiba-u.jp
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Cardiomegaly / pathology,  physiopathology*
Cell Differentiation
Heart / embryology,  growth & development,  physiology*
Heart Diseases / pathology,  physiopathology
Humans
Myocardial Contraction
Myocytes, Cardiac / cytology
Neovascularization, Physiologic*
Proto-Oncogene Proteins c-akt / genetics,  metabolism*
Signal Transduction*
Sports / physiology
Chemical
Reg. No./Substance:
EC 2.7.11.1/Proto-Oncogene Proteins c-akt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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