Document Detail


Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.
MedLine Citation:
PMID:  3380093     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We detected expression of the c-myb proto-oncogene, which was initially thought to be expressed in a tissue-specific manner in cells of hematopoietic lineage, in human tissues of neuronal origin. Since the level of c-myb expression declined during fetal development, we studied the regulation of its expression in human neuroblastoma cell lines induced to differentiate by retinoic acid. The expression of c-myb declined during the maturation of neuroblastoma cells, and this change was mediated by a decrease in c-myb transcription.
Authors:
C J Thiele; P S Cohen; M A Israel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and cellular biology     Volume:  8     ISSN:  0270-7306     ISO Abbreviation:  Mol. Cell. Biol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-07-25     Completed Date:  1988-07-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8109087     Medline TA:  Mol Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1677-83     Citation Subset:  IM    
Affiliation:
Molecular Genetics Section, National Cancer Institute, Bethesda, Maryland 20892.
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MeSH Terms
Descriptor/Qualifier:
Cell Differentiation / drug effects
Cell Line
Gene Expression Regulation*
Humans
Neuroblastoma
Proto-Oncogenes / drug effects*
RNA, Messenger / genetics,  isolation & purification
Transcription, Genetic / drug effects*
Tretinoin / pharmacology*
Chemical
Reg. No./Substance:
0/RNA, Messenger; 302-79-4/Tretinoin
Comments/Corrections

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