| Regulation by insulin of glucose metabolism in mammary gland of anaesthetized lactating rats. Stimulation of phosphofructokinase-1 by fructose 2,6-bisphosphate and activation of acetyl-CoA carboxylase. | |
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MedLine Citation:
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PMID: 2902845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of insulin on glucose metabolism in mammary gland was studied by the euglycaemic/hyperinsulinaemic-clamp technique. Measurement of metabolite concentrations and enzyme activities in the mammary gland suggests two sites of action of insulin: phosphofructokinase-1 and acetyl-coA carboxylase. The increase in phosphofructokinase-1 activity could be linked to the 2-fold increase in fructose 2,6-bisphosphate concentration, since no change in maximal activity and in sensitivity of the enzyme toward fructose 6-phosphate was detected in vitro. |
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Authors:
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A F Burnol; S Ebner; P Ferré; J Girard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Biochemical journal Volume: 254 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-11-22 Completed Date: 1988-11-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 11-4 Citation Subset: IM |
Affiliation:
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Centre de recherches sur la Nutrition du CNRS, Meudon-Bellevue, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetyl-CoA Carboxylase
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metabolism Animals Blood Glucose / metabolism Enzyme Activation / drug effects Enzyme Induction / drug effects Female Fructosediphosphates / pharmacology Glucose / metabolism* Insulin / blood, pharmacology* Isoenzymes / metabolism Lactation / metabolism* Mammary Glands, Animal / metabolism* Phosphofructokinase-1 / metabolism Pregnancy Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fructosediphosphates; 0/Isoenzymes; 11061-68-0/Insulin; 50-99-7/Glucose; 79082-92-1/fructose 2,6-diphosphate; EC 2.7.1.11/Phosphofructokinase-1; EC 6.4.1.2/Acetyl-CoA Carboxylase |
| Comments/Corrections | |
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