Document Detail

Regulation by insulin of glucose metabolism in mammary gland of anaesthetized lactating rats. Stimulation of phosphofructokinase-1 by fructose 2,6-bisphosphate and activation of acetyl-CoA carboxylase.
MedLine Citation:
PMID:  2902845     Owner:  NLM     Status:  MEDLINE    
The effect of insulin on glucose metabolism in mammary gland was studied by the euglycaemic/hyperinsulinaemic-clamp technique. Measurement of metabolite concentrations and enzyme activities in the mammary gland suggests two sites of action of insulin: phosphofructokinase-1 and acetyl-coA carboxylase. The increase in phosphofructokinase-1 activity could be linked to the 2-fold increase in fructose 2,6-bisphosphate concentration, since no change in maximal activity and in sensitivity of the enzyme toward fructose 6-phosphate was detected in vitro.
A F Burnol; S Ebner; P Ferré; J Girard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  254     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-22     Completed Date:  1988-11-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Centre de recherches sur la Nutrition du CNRS, Meudon-Bellevue, France.
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MeSH Terms
Acetyl-CoA Carboxylase / metabolism
Blood Glucose / metabolism
Enzyme Activation / drug effects
Enzyme Induction / drug effects
Fructosediphosphates / pharmacology
Glucose / metabolism*
Insulin / blood,  pharmacology*
Isoenzymes / metabolism
Lactation / metabolism*
Mammary Glands, Animal / metabolism*
Phosphofructokinase-1 / metabolism
Rats, Inbred Strains
Reg. No./Substance:
0/Blood Glucose; 0/Fructosediphosphates; 0/Isoenzymes; 11061-68-0/Insulin; 50-99-7/Glucose; 79082-92-1/fructose 2,6-diphosphate; EC; EC Carboxylase

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