Document Detail

Regulation by growth factors of angiotensin II type-1 receptor and the alpha subunit of Gq and G11 in bovine adrenal cells.
MedLine Citation:
PMID:  8013389     Owner:  NLM     Status:  MEDLINE    
In the present work we have investigated the effects of several growth factors on the expression of Angiotensin II (A-II) receptors subtype AT1 and their pertussis toxin-insensitive coupling to G-proteins in bovine adrenal fasciculata-reticularis cells (BAC). Insulin, Insulin-like growth factor and basic Fibroblast growth factor increased AT1 receptors (mRNA and binding sites) as well as the alpha subunit of Gq (mRNA and protein) and G11 (protein). These changes were associated with an enhanced A-II-induced inositol phosphate accumulation and cortisol production. In contrast, Transforming growth factor beta 1, which reduced slightly AT1 binding sites, but not the level of alpha q or alpha 11 proteins, did not change the A-II-induced inositol phosphate accumulation. However, this factor, as previously reported, markedly reduced cortisol production.
D Langlois; R Ouali; M C Berthelon; A Derrien; J M Saez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinology     Volume:  135     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-07-26     Completed Date:  1994-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  480-3     Citation Subset:  AIM; IM    
INSERM-INRA U 307, Hôpital Debrousse, Lyon, France.
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MeSH Terms
Adrenal Glands / cytology,  drug effects*,  metabolism*
Cells, Cultured
GTP-Binding Proteins / metabolism
Growth Substances / pharmacology*
Hydrocortisone / biosynthesis
Inositol Phosphates / metabolism
Insulin / pharmacology
RNA, Messenger / metabolism
Receptors, Angiotensin / drug effects,  metabolism*
Reg. No./Substance:
0/Growth Substances; 0/Inositol Phosphates; 0/RNA, Messenger; 0/Receptors, Angiotensin; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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